Bellini duct carcinoma
Encyclopedia
Bellini duct carcinoma is a type of kidney cancer
that originates in the duct of Bellini
of the kidney. It is rare, accounting for 1-3% of all kidney cancers. It is also recently described; a 2002 review found just 40 case reports worldwide. Previously, due to its location, BDC was commonly diagnosed as renal cell carcinoma
or a subtype of renal cell carcinoma. However, BDC does not respond well to chemotherapy
drugs used for renal cell carcinoma, and progresses and spreads more quickly. One small study reporting 20% survival at 2 years.. BDC may be related to urothelial carcinoma aka transitional cell carcinoma
, and case reports of treating BDC as for transitional cell carcinoma indicate some benefit.
BDC is extremely rare, and thus hard to study. Currently, very few published works compare histopathological and clinical data. Because of this, there is no standard protocol for its diagnosis and treatment.
histochemistry" helped forward knowledge of kidney duct cancers.
Kidney cancer
Kidney cancer is a type of cancer that starts in the cells in the kidney.The two most common types of kidney cancer are renal cell carcinoma and urothelial cell carcinoma of the renal pelvis...
that originates in the duct of Bellini
Duct of Bellini
The duct of Bellini is an anatomical structure of the kidneys, also known as papillary duct.The straight or collecting tubes commence in the radiate part of the renal cortex, where they receive the curved ends of the distal convoluted tubules.They unite at short intervals with one another, the...
of the kidney. It is rare, accounting for 1-3% of all kidney cancers. It is also recently described; a 2002 review found just 40 case reports worldwide. Previously, due to its location, BDC was commonly diagnosed as renal cell carcinoma
Renal cell carcinoma
Renal cell carcinoma is a kidney cancer that originates in the lining of the proximal convoluted tubule, the very small tubes in the kidney that filter the blood and remove waste products. RCC is the most common type of kidney cancer in adults, responsible for approximately 80% of cases...
or a subtype of renal cell carcinoma. However, BDC does not respond well to chemotherapy
Chemotherapy
Chemotherapy is the treatment of cancer with an antineoplastic drug or with a combination of such drugs into a standardized treatment regimen....
drugs used for renal cell carcinoma, and progresses and spreads more quickly. One small study reporting 20% survival at 2 years.. BDC may be related to urothelial carcinoma aka transitional cell carcinoma
Transitional cell carcinoma
Transitional cell carcinoma is a type of cancer that typically occurs in the urinary system: the kidney, urinary bladder, and accessory organs. It is the most common type of bladder cancer and cancer of the ureter, urethra, and urachus...
, and case reports of treating BDC as for transitional cell carcinoma indicate some benefit.
BDC is extremely rare, and thus hard to study. Currently, very few published works compare histopathological and clinical data. Because of this, there is no standard protocol for its diagnosis and treatment.
Histology
This cancer has a distinctive "bubble wrap" appearance. It has been reported to occur together with urothelial carcinoma of the bladder, and a cancer with intermediate histology also has been reported, leading to the suspicion that these cancers are related.History
BDC was thought to be renal cell carcinoma, until "recently developed techniques of lectinLectin
Lectins are sugar-binding proteins that are highly specific for their sugar moieties. They play a role in biological recognition phenomena involving cells and proteins. For example, some viruses use lectins to attach themselves to the cells of the host organism during infection...
histochemistry" helped forward knowledge of kidney duct cancers.