Benzoyl-CoA
Encyclopedia
Benzoyl-CoA is a molecule implied in the activity of the different enzymes 4-hydroxybenzoyl-CoA reductase
, benzoyl-CoA reductase
, benzoyl-CoA 3-monooxygenase
, benzoate-CoA ligase
, 2alpha-hydroxytaxane 2-O-benzoyltransferase
, anthranilate N-benzoyltransferase
, biphenyl synthase
, glycine N-benzoyltransferase
, ornithine N-benzoyltransferase
and phenylglyoxylate dehydrogenase (acylating)
.
It is a substrate in the formation of xanthonoid
s in Hypericum androsaemum
by benzophenone synthase
condensing a molecule of benzoyl-CoA with three malonyl-CoA
yielding to 2,4,6-trihydroxybenzophenone. This intermediate is subsequently converted by a benzophenone 3′-hydroxylase, a cytochrome P450 monooxygenase, leading to the formation of 2,3′,4,6-tetrahydroxybenzophenone.
4-hydroxybenzoyl-CoA reductase
In enzymology, a 4-hydroxybenzoyl-CoA reductase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are benzoyl-CoA, acceptor, and H2O, whereas its two products are 4-hydroxybenzoyl-CoA and reduced acceptor....
, benzoyl-CoA reductase
Benzoyl-CoA reductase
In enzymology, a benzoyl-CoA reductase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are benzoyl-CoA, reduced acceptor, ATP, and H2O, whereas its 4 products are cyclohexa-1,5-diene-1-carbonyl-CoA, acceptor, ADP, and phosphate.This enzyme belongs to the family of...
, benzoyl-CoA 3-monooxygenase
Benzoyl-CoA 3-monooxygenase
In enzymology, a benzoyl-CoA 3-monooxygenase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are benzoyl-CoA, NADPH, H+, and O2, whereas its 3 products are 3-hydroxybenzoyl-CoA, NADP+, and H2O....
, benzoate-CoA ligase
Benzoate-CoA ligase
In enzymology, a benzoate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, benzoate, and CoA, whereas its 3 products are AMP, diphosphate, and benzoyl-CoA....
, 2alpha-hydroxytaxane 2-O-benzoyltransferase
2alpha-hydroxytaxane 2-O-benzoyltransferase
In enzymology, a 2alpha-hydroxytaxane 2-O-benzoyltransferase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are benzoyl-CoA and 10-deacetyl-2-debenzoylbaccatin III, whereas its two products are CoA and 10-deacetylbaccatin III.This enzyme belongs to the...
, anthranilate N-benzoyltransferase
Anthranilate N-benzoyltransferase
In enzymology, an anthranilate N-benzoyltransferase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are benzoyl-CoA and anthranilate, whereas its two products are CoA and N-benzoylanthranilate....
, biphenyl synthase
Biphenyl synthase
In enzymology, a biphenyl synthase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are malonyl-CoA and benzoyl-CoA, whereas its 3 products are CoA, 3,5-dihydroxybiphenyl, and CO2....
, glycine N-benzoyltransferase
Glycine N-benzoyltransferase
In enzymology, a glycine N-benzoyltransferase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are benzoyl-CoA and glycine, whereas its two products are CoA and N-benzoylglycine....
, ornithine N-benzoyltransferase
Ornithine N-benzoyltransferase
In enzymology, an ornithine N-benzoyltransferase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are benzoyl-CoA and L-ornithine, whereas its two products are CoA and N2,N5-dibenzoyl-L-ornithine....
and phenylglyoxylate dehydrogenase (acylating)
Phenylglyoxylate dehydrogenase (acylating)
In enzymology, a phenylglyoxylate dehydrogenase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are phenylglyoxylate, NAD+, and CoA-SH, whereas its 3 products are benzoyl-S-CoA, CO2, and NADH....
.
It is a substrate in the formation of xanthonoid
Xanthonoid
A xanthonoid is a chemical natural phenolic compound formed from the xanthone backbone. Many members of the Clusiaceae contain xanthonoids.Xanthonoid biosynthesis in cell cultures of Hypericum androsaemum involves the presence of a benzophenone synthase condensing a molecule of benzoyl-CoA with...
s in Hypericum androsaemum
Hypericum androsaemum
Hypericum androsaemum, commonly known as tutsan, is a plant in the genus Hypericum native to open woods and hillsides in Eurasia. It is a perennial shrub reaching up to 1.5 m in height.-Common name:...
by benzophenone synthase
Benzophenone synthase
In enzymology, a benzophenone synthase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are malonyl-CoA and 3-hydroxybenzoyl-CoA, whereas its 3 products are CoA, 2,3',4,6-tetrahydroxybenzophenone, and CO2....
condensing a molecule of benzoyl-CoA with three malonyl-CoA
Malonyl-CoA
Malonyl-CoA is a coenzyme A derivative.-Functions:It plays a key role in chain elongation in fatty acid biosynthesis and polyketide biosynthesis....
yielding to 2,4,6-trihydroxybenzophenone. This intermediate is subsequently converted by a benzophenone 3′-hydroxylase, a cytochrome P450 monooxygenase, leading to the formation of 2,3′,4,6-tetrahydroxybenzophenone.