Besonprodil
Encyclopedia
Besonprodil is a drug which acts as an NMDA antagonist, selective for the NR2B subunit. It is under development as a supplemental medication for Parkinson's disease
, and has been shown in animals to be effective in counteracting the dyskinesia
s associated with long term treatment with levodopa
and related drugs.
Parkinson's disease
Parkinson's disease is a degenerative disorder of the central nervous system...
, and has been shown in animals to be effective in counteracting the dyskinesia
Dyskinesia
Dyskinesia is a movement disorder which consists of effects including diminished voluntary movements and the presence of involuntary movements, similar to tics or choreia. Dyskinesia can be anything from a slight tremor of the hands to uncontrollable movement of, most commonly, the upper body but...
s associated with long term treatment with levodopa
Levodopa
L-DOPA is a chemical that is made and used as part of the normal biology of some animals and plants. Some animals including humans make it via biosynthesis from the amino acid L-tyrosine. L-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine , and epinephrine collectively...
and related drugs.