• Big Run, Jefferson County, Pennsylvania
• Big Run, Marion County, West Virginia
  Big Run, Marion County, West Virginia
  Big Run is an unincorporated community in Marion County, West Virginia, United States. It lies along Big Run, the stream from which it takes its name....
  
  
• Big Run, Marshall County, West Virginia
  Big Run, Marshall County, West Virginia
  Big Run is an unincorporated community on U.S. Route 250 in Marshall County, West Virginia, United States....
  
  
• Big Run, Webster County, West Virginia
  Big Run, Webster County, West Virginia
  Big Run is an unincorporated community on the Right Fork of the Holly River in Webster County, West Virginia, United States....
  
  
• Big Run, Wetzel County, West Virginia
  Big Run, Wetzel County, West Virginia
  Big Run is an unincorporated community in Wetzel County, West Virginia, United States. It is named for Big Run on which it is located....
  
  

Other uses

• Big Run (South Branch Potomac River tributary) in Hampshire County, West Virginia
• Big Run
  Big Run (arcade game)
  Big Run is a 3D rally racing arcade game released by Jaleco in 1989. The game is the first to be set in the famous Paris-Dakar rally raid which the player drives a Porsche 959, resembling that of the 1986 winner. Opponents in the game seem to resemble the Peugeot 205 T16, which went on to win in...
  
  , a 1989 arcade game developed by Jaleco