BioLineRx
Encyclopedia
BioLineRx or BioLine, is a publicly traded drug development company that seeks to discover compounds for disease treatment and develop them into commercializable drugs. Headquartered in Israel
, its shares are traded on the NASDAQ Capital Market
and on the Tel Aviv Stock Exchange
.
and engages other companies to advance the compounds' development into commercializable drugs. The company entered into its first major commercialization agreement in 2009 when it partnered with Ikaria Holdings Inc. to develop its BL-1040 compound. In 2010 BioLine entered into a commercialization agreement with Cypress Bioscience Inc. for development of its BL-1020 compound. The agreement with Cypress was canceled in 2011 when the company was taken over by Ramius LLC.
by BioLineRx. Unless indicated otherwise, they have not obtained regulatory approval in relation to the diseases cited.
consists of three stages. In the first stage, called the bench stage, the potential drug candidate is evaluated "from both scientific and marketing perspectives." In the second stage, called the bedside stage, BioLine accompanies the drug through early clinical trial
s. In the third stage, the partner stage, BioLine enters into strategic partnership with a pharmaceutical company to see the drug through its advanced clinical trials and bring it to the market.
, Hadasit Bio-Holdings, the Jerusalem Development Authority, Yehuda Zisapel, and other investors. It executed an initial public offering
on the Tel Aviv Stock Exchange in February 2007, raising NIS 211 million ($50 million) – the TASE's largest biotech IPO until that time. In August 2011 BioLine's ADRs
began trading on the NASDAQ Capital Market.
(B.Sc.) alumnus, was CEO of BioLineRx until 2009. He was replaced by Kinneret Savitsky, almunus of Tel Aviv University
(Master's and Ph.D.) and the Hebrew University of Jerusalem (B.Sc.), early in 2010.
Israel
The State of Israel is a parliamentary republic located in the Middle East, along the eastern shore of the Mediterranean Sea...
, its shares are traded on the NASDAQ Capital Market
NASDAQ Capital Market
Originally called the NASDAQ Small Cap Market, NASDAQ announced a name change to the NASDAQ Capital Market on September 27, 2005.The NASDAQ Capital Market exists for securities of smaller, less-capitalized companies that do not qualify for inclusion in the Nasdaq National Market....
and on the Tel Aviv Stock Exchange
Tel Aviv Stock Exchange
The Tel Aviv Stock Exchange in Tel Aviv is Israel's only stock exchange.The TASE is the only public market for trading securities in Israel. It plays a major role in the Israeli economy....
.
Operations
BioLineRx is a drug development company that seeks to discover compounds with potential to treat a variety of diseases, including cancer, schizophrenia and cardiac deterioration. When promising compounds are discovered, BioLine leads them through preclinical trialsPre-clinical development
In drug development, pre-clinical development is a stage of research that begins before clinical trials can begin, and during which important feasibility, iterative testing and drug safety data is collected....
and engages other companies to advance the compounds' development into commercializable drugs. The company entered into its first major commercialization agreement in 2009 when it partnered with Ikaria Holdings Inc. to develop its BL-1040 compound. In 2010 BioLine entered into a commercialization agreement with Cypress Bioscience Inc. for development of its BL-1020 compound. The agreement with Cypress was canceled in 2011 when the company was taken over by Ramius LLC.
Pipeline
Below is a partial list of drug compounds in various stages of developmentProduct Pipeline
A product pipeline is a series of products developed and sold by a company, ideally in different stages of their life cycle. Having at any point in a company's life some products in the growth and mature stage of the life cycle is the goal....
by BioLineRx. Unless indicated otherwise, they have not obtained regulatory approval in relation to the diseases cited.
- BL-1020 – orally available GABAGabâGabâ or gabaa, for the people in many parts of the Philippines), is the concept of a non-human and non-divine, imminent retribution. A sort of negative karma, it is generally seen as an evil effect on a person because of their wrongdoings or transgressions...
-enhanced antipsychotic for treatment of schizophreniaSchizophreniaSchizophrenia is a mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests itself as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social... - BL-1021 – orally available small moleculeSmall moleculeIn the fields of pharmacology and biochemistry, a small molecule is a low molecular weight organic compound which is by definition not a polymer...
for treatment of neuropathic painNeuropathic painNeuropathic pain results from lesions or diseases affecting the somatosensory system. It may be associated with abnormal sensations called dysesthesia, which occur spontaneously and allodynia that occurs in response to external stimuli. Neuropathic pain may have continuous and/or episodic ... - BL-1040 – liquid polymer injected into patients suffering from acute myocardial infarction, invented by Smadar Cohen of Ben-Gurion University
- BL-5010 – cream treatment for seborrheic keratosisSeborrheic keratosisA seborrheic keratosis is a noncancerous benign skin growth that originates in keratinocytes. Like liver spots, seborrheic keratoses are seen more often as people age. In fact they are sometimes humorously referred to as the "barnacles of old age". They appear in various colors, from light tan to...
skin lesions - BL-7040 – orally available anti-inflammatory drug invented by Hermona Soreq of the Hebrew University of JerusalemHebrew University of JerusalemThe Hebrew University of Jerusalem ; ; abbreviated HUJI) is Israel's second-oldest university, after the Technion – Israel Institute of Technology. The Hebrew University has three campuses in Jerusalem and one in Rehovot. The world's largest Jewish studies library is located on its Edmond J...
Business model
BioLine's business modelBusiness model
A business model describes the rationale of how an organization creates, delivers, and captures value...
consists of three stages. In the first stage, called the bench stage, the potential drug candidate is evaluated "from both scientific and marketing perspectives." In the second stage, called the bedside stage, BioLine accompanies the drug through early clinical trial
Clinical trial
Clinical trials are a set of procedures in medical research and drug development that are conducted to allow safety and efficacy data to be collected for health interventions...
s. In the third stage, the partner stage, BioLine enters into strategic partnership with a pharmaceutical company to see the drug through its advanced clinical trials and bring it to the market.
Corporate history
BioLineRx was established in 2003 as a joint venture of TevaTeva Pharmaceutical Industries
Teva Pharmaceutical Industries Ltd. , is an international pharmaceutical company headquartered in Petah Tikva, Israel. It specializes in generic and proprietary pharmaceuticals and active pharmaceutical ingredients...
, Hadasit Bio-Holdings, the Jerusalem Development Authority, Yehuda Zisapel, and other investors. It executed an initial public offering
Initial public offering
An initial public offering or stock market launch, is the first sale of stock by a private company to the public. It can be used by either small or large companies to raise expansion capital and become publicly traded enterprises...
on the Tel Aviv Stock Exchange in February 2007, raising NIS 211 million ($50 million) – the TASE's largest biotech IPO until that time. In August 2011 BioLine's ADRs
American Depositary Receipt
An American depositary receipt is a negotiable security that represents the underlying securities of a non-U.S. company that trades in the US financial markets...
began trading on the NASDAQ Capital Market.
Management
Morris Laster, Downstate Medical Center (M.D.) and SUNY AlbanyUniversity at Albany, SUNY
The State University of New York at Albany, also known as University at Albany, State University of New York, SUNY Albany or simply UAlbany, is a public university located in Albany, Guilderland, and East Greenbush, New York, United States; is the senior campus of the State University of New York ...
(B.Sc.) alumnus, was CEO of BioLineRx until 2009. He was replaced by Kinneret Savitsky, almunus of Tel Aviv University
Tel Aviv University
Tel Aviv University is a public university located in Ramat Aviv, Tel Aviv, Israel. With nearly 30,000 students, TAU is Israel's largest university.-History:...
(Master's and Ph.D.) and the Hebrew University of Jerusalem (B.Sc.), early in 2010.
See also
- Translational medicineTranslational medicineTranslational medicine is a medical practice based on interventional epidemiology. It is regarded by its proponents as a natural progression from Evidence-Based Medicine. It integrates research from the basic sciences, social sciences and political sciences with the aim of optimising patient care...
- TA BlueTech-50 IndexTA BlueTech-50 IndexThe TA BlueTech-50 Index is a stock market index of the 50 most highly capitalised Information technology and Biotechnology companies listed on the Tel Aviv Stock Exchange...
- List of Israeli companies quoted on the Nasdaq