Bistramide A
Encyclopedia
Bistramide A is a chemical compound originally found in the marine ascidian Lissoclinum bistratum.

It was found that the cyclic portion of the synthesis proceeds through a Petkov transition-state model followed by an asymmetric [4+2] Robinson annulation
Robinson annulation
The Robinson annulation is an organic reaction used to create a six-member ring α,β-unsaturated cyclic ketone, using a ketone and methyl vinyl ketone...

into the desired diamide product.

A more efficient crystallization was further described by J. Job, M.D., where a Kalmanson catalyst is used to quickly build up and break down the Petkov transition-state, followed by a Berne backside attack, which instantaneously causes the precipitation of the product.
The source of this article is wikipedia, the free encyclopedia.  The text of this article is licensed under the GFDL.
 
x
OK