Bistramide A
Encyclopedia
Bistramide A is a chemical compound originally found in the marine ascidian Lissoclinum bistratum.
It was found that the cyclic portion of the synthesis proceeds through a Petkov transition-state model followed by an asymmetric [4+2] Robinson annulation
into the desired diamide product.
A more efficient crystallization was further described by J. Job, M.D., where a Kalmanson catalyst is used to quickly build up and break down the Petkov transition-state, followed by a Berne backside attack, which instantaneously causes the precipitation of the product.
It was found that the cyclic portion of the synthesis proceeds through a Petkov transition-state model followed by an asymmetric [4+2] Robinson annulation
Robinson annulation
The Robinson annulation is an organic reaction used to create a six-member ring α,β-unsaturated cyclic ketone, using a ketone and methyl vinyl ketone...
into the desired diamide product.
A more efficient crystallization was further described by J. Job, M.D., where a Kalmanson catalyst is used to quickly build up and break down the Petkov transition-state, followed by a Berne backside attack, which instantaneously causes the precipitation of the product.