Brivaracetam
Encyclopedia
Brivaracetam, the 4-n-propyl analog of levetiracetam, is a racetam
derivative with anticonvulsant
properties. Brivaracetam is believed to act by binding to the ubiquitous synaptic vesicle protein SV2. Phase II clinical trials in adult patients with refractory partial seizures were promising. Positive preliminary results from stage III trials have been recorded , along with evidence that it is around 10 times more potent for the prevention of certain types of seizure in mouse models than levetiracetam, of which it is an analogue.
Racetam
Racetams are a class of nootropic drugs that share a pyrrolidone nucleus.-Mechanism:There is no generally accepted mechanism for racetams. They generally show no affinity for the most important receptors, although modulation of most important central neurotransmitters, including acetylcholine and...
derivative with anticonvulsant
Anticonvulsant
The anticonvulsants are a diverse group of pharmaceuticals used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of bipolar disorder, since many seem to act as mood stabilizers, and in the treatment of neuropathic pain. The goal of an...
properties. Brivaracetam is believed to act by binding to the ubiquitous synaptic vesicle protein SV2. Phase II clinical trials in adult patients with refractory partial seizures were promising. Positive preliminary results from stage III trials have been recorded , along with evidence that it is around 10 times more potent for the prevention of certain types of seizure in mouse models than levetiracetam, of which it is an analogue.