CBV (chemotherapy)
Encyclopedia
CBV refers to Cytoxan (cyclophosphamide)
, BCNU (carmustine), and VP-16 (etoposide), three drugs in a chemotherapy
regimen commonly given to lymphoma
patients in conjunction with stem cell
therapy CBV is usually given in high doses to patients who have relapse
d or who have refractory disease and cannot benefit from standard chemotherapy. Since a patient's bone marrow is virtually guaranteed not to survive a course of CBV, the receiving patient must receive a transplant (allogenic or autologous, depending on his or her condition) of stem cells (formerly referred to as a bone marrow transplant
) to replace the patient's own hemopoietic ("blood-forming") stem cells.
Cyclophosphamide
Cyclophosphamide , also known as cytophosphane, is a nitrogen mustard alkylating agent, from the oxazophorines group....
, BCNU (carmustine), and VP-16 (etoposide), three drugs in a chemotherapy
Chemotherapy
Chemotherapy is the treatment of cancer with an antineoplastic drug or with a combination of such drugs into a standardized treatment regimen....
regimen commonly given to lymphoma
Lymphoma
Lymphoma is a cancer in the lymphatic cells of the immune system. Typically, lymphomas present as a solid tumor of lymphoid cells. Treatment might involve chemotherapy and in some cases radiotherapy and/or bone marrow transplantation, and can be curable depending on the histology, type, and stage...
patients in conjunction with stem cell
Stem cell
This article is about the cell type. For the medical therapy, see Stem Cell TreatmentsStem cells are biological cells found in all multicellular organisms, that can divide and differentiate into diverse specialized cell types and can self-renew to produce more stem cells...
therapy CBV is usually given in high doses to patients who have relapse
Relapse
Relapse, in relation to drug misuse, is resuming the use of a drug or a dependent substance after one or more periods of abstinence. The term is a landmark feature of both substance dependence and substance abuse, which are learned behaviors, and is maintained by neuronal adaptations that mediate...
d or who have refractory disease and cannot benefit from standard chemotherapy. Since a patient's bone marrow is virtually guaranteed not to survive a course of CBV, the receiving patient must receive a transplant (allogenic or autologous, depending on his or her condition) of stem cells (formerly referred to as a bone marrow transplant
Bone marrow transplant
Hematopoietic stem cell transplantation is the transplantation of multipotent hematopoietic stem cell or blood, usually derived from bone marrow, peripheral blood stem cells, or umbilical cord blood...
) to replace the patient's own hemopoietic ("blood-forming") stem cells.