CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

 which resides on chromosome 11.

Function

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma

CD3G

T-cell surface glycoprotein CD3 gamma chain is a protein that in humans is encoded by the CD3G gene.-Further reading:...

, -delta

CD3D

T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.-Further reading:...

 and -zeta

CD247

T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 is a protein that in humans is encoded by the CD247 gene.- Genomics :...

, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor

T cell receptor

The T cell receptor or TCR is a molecule found on the surface of T lymphocytes that is responsible for recognizing antigens bound to major histocompatibility complex molecules...

-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.

Clinical significance

Defects in this gene cause severe immunodeficiency

Immunodeficiency

Immunodeficiency is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent. Immunodeficiency may also decrease cancer immunosurveillance. Most cases of immunodeficiency are acquired but some people are born with defects in their immune system,...

. This gene has also been linked to a susceptibility to type I diabetes in women.

Interactions

T-cell surface glycoprotein CD3 epsilon chain has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with TOP2B

TOP2B

DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene.-Interactions:TOP2B has been shown to interact with BAZ1B, HDAC1, Histone deacetylase 2, T-cell surface glycoprotein CD3 epsilon chain, Small ubiquitin-related modifier 1 and P53.-Further reading:...

, CD3EAP

CD3EAP

DNA-directed RNA polymerase I subunit RPA34 is an enzyme that in humans is encoded by the CD3EAP gene.-Interactions:CD3EAP has been shown to interact with T-cell surface glycoprotein CD3 epsilon chain, POLR1E and POLR1C.-Further reading:...

 and NCK2

NCK2

Cytoplasmic protein NCK2 is a protein that in humans is encoded by the NCK2 gene.-Interactions:NCK2 has been shown to interact with LIMS1, Epidermal growth factor receptor, PDGFRB, PTK2, T-cell surface glycoprotein CD3 epsilon chain and TrkB....

.

Further reading