CD58
Encyclopedia
CD58, or lymphocyte function-associated antigen
3 (LFA-3), is a cell adhesion molecule
expressed on Antigen Presenting Cells (APC), particularly macrophages.
It binds to CD2
(aka, LFA-2) on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation, when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T cell's "T cell Receptors" (TCR) are reactive to.
Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.
Lymphocyte function-associated antigen
Lymphocyte function-associated antigen can refer to:* LFA-1* LFA-2* LFA-3...
3 (LFA-3), is a cell adhesion molecule
Cell adhesion molecule
Cell Adhesion Molecules are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix in the process called cell adhesion....
expressed on Antigen Presenting Cells (APC), particularly macrophages.
It binds to CD2
CD2
CD2 is a cell adhesion molecule found on the surface of T cells and natural killer cells.It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor....
(aka, LFA-2) on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation, when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T cell's "T cell Receptors" (TCR) are reactive to.
Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.