CENTG2
Encyclopedia
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 is an enzyme
that in humans is encoded by the AGAP1 gene
.
2). HACNS1 is hypothesized to be a gene enhancer "that may have contributed to the evolution of the uniquely opposable human
thumb
, and possibly also modifications in the ankle
or foot
that allow humans to walk
on two legs". Evidence to date shows that of the 110,000 gene enhancer sequences identified in the human genome
, HACNS1 has undergone the most change during the evolution
of humans following the split with the ancestors of chimpanzee
s.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the AGAP1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
HACNS1
HACNS1 is located in an intron of the gene CENTG2 (also known as Human Accelerated RegionHuman accelerated regions
Human accelerated regions , first described in August 2006, are a set of 49 segments of the human genome which are conserved throughout vertebrate evolution but are strikingly different in humans. They are named HAR1 through HAR49 according to their degree of difference between humans and chimpanzees...
2). HACNS1 is hypothesized to be a gene enhancer "that may have contributed to the evolution of the uniquely opposable human
Human
Humans are the only living species in the Homo genus...
thumb
Thumb
The thumb is the first digit of the hand. When a person is standing in the medical anatomical position , the thumb is the lateral-most digit...
, and possibly also modifications in the ankle
Ankle
The ankle joint is formed where the foot and the leg meet. The ankle, or talocrural joint, is a synovial hinge joint that connects the distal ends of the tibia and fibula in the lower limb with the proximal end of the talus bone in the foot...
or foot
Foot
The foot is an anatomical structure found in many vertebrates. It is the terminal portion of a limb which bears weight and allows locomotion. In many animals with feet, the foot is a separate organ at the terminal part of the leg made up of one or more segments or bones, generally including claws...
that allow humans to walk
WALK
WALK may refer to:*WALK , a radio station licensed to East Patchogue, New York, United States*WALK-FM, a radio station licensed to Patchogue, New York, United States...
on two legs". Evidence to date shows that of the 110,000 gene enhancer sequences identified in the human genome
Genome
In modern molecular biology and genetics, the genome is the entirety of an organism's hereditary information. It is encoded either in DNA or, for many types of virus, in RNA. The genome includes both the genes and the non-coding sequences of the DNA/RNA....
, HACNS1 has undergone the most change during the evolution
Evolution
Evolution is any change across successive generations in the heritable characteristics of biological populations. Evolutionary processes give rise to diversity at every level of biological organisation, including species, individual organisms and molecules such as DNA and proteins.Life on Earth...
of humans following the split with the ancestors of chimpanzee
Chimpanzee
Chimpanzee, sometimes colloquially chimp, is the common name for the two extant species of ape in the genus Pan. The Congo River forms the boundary between the native habitat of the two species:...
s.