CIITA
Overview
 
CIITA is a human gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

 which encodes a protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 called the class II, major histocompatibility complex, transactivator. Mutations in this gene are responsible for the bare lymphocyte syndrome
Bare lymphocyte syndrome
Bare lymphocyte syndrome is a condition caused by mutations in certain genes of the major histocompatibility complex. It is a form of severe combined immunodeficiency.-Presentation:...

 in which the immune system
Immune system
An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens and tumor cells. It detects a wide variety of agents, from viruses to parasitic worms, and needs to distinguish them from the organism's own...

 is severely compromised and cannot effectively fight infection
Infection
An infection is the colonization of a host organism by parasite species. Infecting parasites seek to use the host's resources to reproduce, often resulting in disease...

. Chromosomal rearrangement of CIITA is involved in the pathogenesis of Hodgkin lymphoma and primary mediastinal B cell lymphoma.
CIITA mRNA
Messenger RNA
Messenger RNA is a molecule of RNA encoding a chemical "blueprint" for a protein product. mRNA is transcribed from a DNA template, and carries coding information to the sites of protein synthesis: the ribosomes. Here, the nucleic acid polymer is translated into a polymer of amino acids: a protein...

 can only be detected in human leukocyte antigen
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

 (HLA) system class II-positive cell lines and tissues.
Quotations

[reading a sign from dumpster] "Warning! Do not play in or around dumpster. Do not kick dumpster. Do not sleep in dumpster. Usage of this container for the disposal of human remains, may be in violation of local health ordinances."

[looking at the boxes] Empty boxes. They really should be flattend, so they can be recycled.

[looking for his keys] Some joker took my keys. I don't like that.

[looking at his bike] Good thing Ripburger didn't touch my bike. Good thing for him.

[knocking on the door of the Kickstand] Open up!

When I'm on the road, I'm indestructible. No one can stop me... but they try.

[trying to open Todd Newlan's trailer door]: Knock knock.. Open up Todd!

[looking at Todd's basement window from outside]: Either someone's doing some welding down there, or we're talking about some very sub-code wiring.

 
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