CLASP1
Encyclopedia
Cytoplasmic linker associated protein 1, also known as CLASP1 is a protein
which in humans is encoded by the CLASP1 gene
.
s involved in attachment of microtubule
s to the cell cortex
in animals and plants. CLASPs, such as CLASP1, interact with CLIPs (e.g., CLIP1
). In animal cells, CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore
and throughout the spindle.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
which in humans is encoded by the CLASP1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
CLASP1 belongs to a family of microtubule-associated proteinMicrotubule-associated protein
In cell biology, microtubule-associated proteins are proteins that interact with the microtubules of the cellular cytoskeleton.-Function:...
s involved in attachment of microtubule
Microtubule
Microtubules are a component of the cytoskeleton. These rope-like polymers of tubulin can grow as long as 25 micrometers and are highly dynamic. The outer diameter of microtubule is about 25 nm. Microtubules are important for maintaining cell structure, providing platforms for intracellular...
s to the cell cortex
Cell cortex
The cell cortex is a specialized layer of cytoplasm on the inner face of the plasma membrane that functions as a mechanical support of the plasma membrane. In animal cells it is an actin-rich layer responsible for movements of the cell surface. In plant cells, the cell cortex is reinforced by...
in animals and plants. CLASPs, such as CLASP1, interact with CLIPs (e.g., CLIP1
CLIP1
CAP-GLY domain containing linker protein 1, also known as CLIP1, is a protein which in humans is encoded by the CLIP1 gene.-Interactions:CLIP1 has been shown to interact with IQGAP1, Mammalian target of rapamycin and PAFAH1B1.-Further reading:...
). In animal cells, CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore
Kinetochore
The kinetochore is the protein structure on chromatids where the spindle fibers attach during cell division to pull sister chromatids apart....
and throughout the spindle.