In molecular biology, the CUT domain (also known as ONECUT) is a DNA

DNA

Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...

-binding motif which can bind independently or in cooperation with the homeodomain, which is often found downstream of the CUT domain. Protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

s display two modes of DNA binding, which hinge on the homeodomain and on the linker that separates it from the CUT domain, and two modes of transcriptional

Transcription (genetics)

Transcription is the process of creating a complementary RNA copy of a sequence of DNA. Both RNA and DNA are nucleic acids, which use base pairs of nucleotides as a complementary language that can be converted back and forth from DNA to RNA by the action of the correct enzymes...

stimulation, which hinge on the homeodomain.