Cancer Genome Project
Encyclopedia
The Cancer Genome Project, based at the Wellcome Trust
Sanger Institute
, aims to identify sequence variant
s/mutation
s critical in the development of human cancer
s. Like The Cancer Genome Atlas
project within the United States, the Cancer Genome Project represents an effort in the War on Cancer
to improve cancer diagnosis, treatment, and prevention through a better understanding of the molecular basis of this disease.
The Cancer Genome Project, led by Michael Stratton
and Andy Futreal, combines knowledge of the human genome
sequence with high throughput mutation detection
techniques.
Wellcome Trust
The Wellcome Trust was established in 1936 as an independent charity funding research to improve human and animal health. With an endowment of around £13.9 billion, it is the United Kingdom's largest non-governmental source of funds for biomedical research...
Sanger Institute
Sanger Institute
The Wellcome Trust Sanger Institute is a non-profit, British genomics and genetics research institute, primarily funded by the Wellcome Trust....
, aims to identify sequence variant
Genetic variation
Genetic variation, variation in alleles of genes, occurs both within and among populations. Genetic variation is important because it provides the “raw material” for natural selection. Genetic variation is brought about by mutation, a change in a chemical structure of a gene. Polyploidy is an...
s/mutation
Mutation
In molecular biology and genetics, mutations are changes in a genomic sequence: the DNA sequence of a cell's genome or the DNA or RNA sequence of a virus. They can be defined as sudden and spontaneous changes in the cell. Mutations are caused by radiation, viruses, transposons and mutagenic...
s critical in the development of human cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
s. Like The Cancer Genome Atlas
The Cancer Genome Atlas
The Cancer Genome Atlas is a project to catalogue genetic mutations responsible for cancer, using genome analysis techniques started in 2005...
project within the United States, the Cancer Genome Project represents an effort in the War on Cancer
War on Cancer
The War on Cancer refers to the effort to find a cure for cancer by increased research to improve the understanding of cancer biology and the development of more effective cancer treatments, such as targeted drug therapies. The aim of such efforts is to eradicate cancer as a major cause of death....
to improve cancer diagnosis, treatment, and prevention through a better understanding of the molecular basis of this disease.
The Cancer Genome Project, led by Michael Stratton
Michael Stratton
Professor Michael Rudolf Stratton, FRS is a British clinical scientist and the third Director of the Wellcome Trust Sanger Institute. He currently heads the Cancer Genome Project and is a leader of the International Cancer Genome Consortium.- Career :...
and Andy Futreal, combines knowledge of the human genome
Human genome
The human genome is the genome of Homo sapiens, which is stored on 23 chromosome pairs plus the small mitochondrial DNA. 22 of the 23 chromosomes are autosomal chromosome pairs, while the remaining pair is sex-determining...
sequence with high throughput mutation detection
High-throughput screening
High-throughput screening is a method for scientific experimentation especially used in drug discovery and relevant to the fields of biology and chemistry. Using robotics, data processing and control software, liquid handling devices, and sensitive detectors, High-Throughput Screening allows a...
techniques.
See also
- Cancer genome sequencingCancer genome sequencingCancer genome sequencing is the resequencing of genomes of several human cancers.It is an effort and a necessity, in the War on Cancer to improve cancer diagnosis, treatment, and prevention through a better understanding of the molecular basis of this disease...
- The Cancer Genome AtlasThe Cancer Genome AtlasThe Cancer Genome Atlas is a project to catalogue genetic mutations responsible for cancer, using genome analysis techniques started in 2005...
and The Cancer Genome Anatomy Project at the National Cancer Institute. - International Cancer Genome ConsortiumInternational Cancer Genome ConsortiumThe International Cancer Genome Consortium is a voluntary scientific organization that provides a forum for collaboration among the world's leading cancer and genomic researchers....
- COSMIC cancer databaseCOSMIC cancer databaseCOSMIC is an online database of somatically acquired mutations found in human cancer. Somatic mutations are those that occur in non-germline cells that are not inherited by children...