The Casamance River flows westward for the most part into the Atlantic Ocean

Atlantic Ocean

The Atlantic Ocean is the second-largest of the world's oceanic divisions. With a total area of about , it covers approximately 20% of the Earth's surface and about 26% of its water surface area...

 along a path about 200 miles (320 km) in length. However, only 80 miles (130 km) of it are navigable. The Casamance is the principal river of the Kolda

Kolda Region

Kolda is a region of Senegal . The region is also referred to historically and popularly as Haute Casamance.-Departments:Kolda region is divided into 3 departments:*Kolda...

, Sédhiou

Sédhiou Region

-Departments:Sédhiou Region has three departments:*Bounkiling Department*Goudoump Department*Sédhiou Department...

, and Ziguinchor

Ziguinchor Region

Ziguinchor is a region of Senegal . The region is also referred to historically and popularly as Basse Casamance.-Departments:Ziguinchor region is divided into 3 departments:*Bignona...

 Regions

Regions of Senegal

||Senegal is subdivided into 14 regions , each of which is administered by a Conseil Régional elected by population weight at the Arrondissement level....

 in the southern portion of Senegal

Senegal

Senegal , officially the Republic of Senegal , is a country in western Africa. It owes its name to the Sénégal River that borders it to the east and north...

 between The Gambia

The Gambia

The Republic of The Gambia, commonly referred to as The Gambia, or Gambia , is a country in West Africa. Gambia is the smallest country on mainland Africa, surrounded by Senegal except for a short coastline on the Atlantic Ocean in the west....

 and Guinea-Bissau

Guinea-Bissau

The Republic of Guinea-Bissau is a country in West Africa. It is bordered by Senegal to the north, and Guinea to the south and east, with the Atlantic Ocean to its west....

. The three regions are also collectively known as Casamance

Casamance

Casamance is the area of Senegal south of The Gambia including the Casamance River. It consists of Basse Casamance and Haute Casamance...

 after the river.

There is a ferry at Ziguinchor

Ziguinchor

Ziguinchor is the capital of the Ziguinchor Region, and the chief town of the Casamance area of Senegal, lying at the mouth of the Casamance River. It has a population of over 230,000...

 in Senegal, one of the most important towns on the river. Other important towns/villages on its banks include Goudomp, Sediou, Diattakounda, Tanae, and Kolda

Kolda

Kolda is a city located in southern Senegal. It is the capital city of Kolda Region, a region known historically and popularly as Haute Casamance.-Physical Geology and Climate:...

.

The next significant estuary to the south is the Farim River

Farim River

The Farim is a river of Guinea-Bissau also known as the Cacheu along its lower length. Its total length is about 257 km.Its headwaters are near the northern border of the country, north of Contobeul and close to a bend of the Geba River...

 in Guinea-Bissau, and to the north, the River Gambia, namesake of The Gambia.