The Central American Seaway, also called the Panamanic Seaway or Inter-American Seaway was an ancient body of water that once separated North America

North America

North America is a continent wholly within the Northern Hemisphere and almost wholly within the Western Hemisphere. It is also considered a northern subcontinent of the Americas...

 from South America

South America

South America is a continent situated in the Western Hemisphere, mostly in the Southern Hemisphere, with a relatively small portion in the Northern Hemisphere. The continent is also considered a subcontinent of the Americas. It is bordered on the west by the Pacific Ocean and on the north and east...

. It formed in the Mesozoic

Mesozoic

The Mesozoic era is an interval of geological time from about 250 million years ago to about 65 million years ago. It is often referred to as the age of reptiles because reptiles, namely dinosaurs, were the dominant terrestrial and marine vertebrates of the time...

 (200-154 mya) during the separation of the Pangaea

Pangaea

Pangaea, Pangæa, or Pangea is hypothesized as a supercontinent that existed during the Paleozoic and Mesozoic eras about 250 million years ago, before the component continents were separated into their current configuration....

n supercontinent, and closed when the Panamanian isthmus was formed by volcanic activity in the late Pliocene

Pliocene

The Pliocene Epoch is the period in the geologic timescale that extends from 5.332 million to 2.588 million years before present. It is the second and youngest epoch of the Neogene Period in the Cenozoic Era. The Pliocene follows the Miocene Epoch and is followed by the Pleistocene Epoch...

 (2.76-2.54 mya).

The closure of the Central American Seaway had tremendous effects on oceanic circulation

Ocean current

An ocean current is a continuous, directed movement of ocean water generated by the forces acting upon this mean flow, such as breaking waves, wind, Coriolis effect, cabbeling, temperature and salinity differences and tides caused by the gravitational pull of the Moon and the Sun...

 and the biogeography

Biogeography

Biogeography is the study of the distribution of species , organisms, and ecosystems in space and through geological time. Organisms and biological communities vary in a highly regular fashion along geographic gradients of latitude, elevation, isolation and habitat area...

 of the adjacent seas, isolating many species and triggering speciation

Speciation

Speciation is the evolutionary process by which new biological species arise. The biologist Orator F. Cook seems to have been the first to coin the term 'speciation' for the splitting of lineages or 'cladogenesis,' as opposed to 'anagenesis' or 'phyletic evolution' occurring within lineages...

 and diversification of tropical and sub-tropical marine fauna. It had an even larger impact on terrestrial life. The seaway had isolated South America for much of the Cenozoic

Cenozoic

The Cenozoic era is the current and most recent of the three Phanerozoic geological eras and covers the period from 65.5 mya to the present. The era began in the wake of the Cretaceous–Tertiary extinction event at the end of the Cretaceous that saw the demise of the last non-avian dinosaurs and...

, allowing the evolution of a wholly unique diverse mammalian fauna there; when it closed, a faunal exchange

Great American Interchange

The Great American Interchange was an important paleozoogeographic event in which land and freshwater fauna migrated from North America via Central America to South America and vice versa, as the volcanic Isthmus of Panama rose up from the sea floor and bridged the formerly separated continents...

with North America ensued, leading to the extinction of many of the native South American forms.