Citatuzumab bogatox
Encyclopedia
Citatuzumab bogatox is a monoclonal antibody Fab fragment fused with bouganin, an ribosome inactivating protein
from the plant Bougainvillea
spectabilis. It has undergone pre-clinical trials for the treatment of ovarian cancer
and other solid tumors.
Ribosome inactivating protein
A ribosome inactivating protein is a protein synthesis inhibitor that acts at the ribosome..A number of bacterial and plant toxins act by inhibiting protein synthesis in eukaryotic cells. The toxins of the Shiga and ricin family inactivate 60S ribosomal subunits by an N-glycosidic cleavage which...
from the plant Bougainvillea
Bougainvillea
Bougainvillea is a genus of flowering plants native to South America from Brazil west to Peru and south to southern Argentina . Different authors accept between four and 18 species in the genus...
spectabilis. It has undergone pre-clinical trials for the treatment of ovarian cancer
Ovarian cancer
Ovarian cancer is a cancerous growth arising from the ovary. Symptoms are frequently very subtle early on and may include: bloating, pelvic pain, difficulty eating and frequent urination, and are easily confused with other illnesses....
and other solid tumors.