Collapsin response mediator protein family
Encyclopedia
Collapsin response mediator protein family or CRMP family consists of five intracellular phosphoproteins (CRMP1
, CRMP2, CRMP3, CRMP4, CRMP5) of similar molecular size (60–66 kDa) and high (50–70%) amino acid sequence identity. CRMPs are predominantly expressed in the nervous system
during development and are parts to the mechanism underlying the repulsive guidance of growth cones.
CRMP1
Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein of the CRMP family.This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system...
, CRMP2, CRMP3, CRMP4, CRMP5) of similar molecular size (60–66 kDa) and high (50–70%) amino acid sequence identity. CRMPs are predominantly expressed in the nervous system
Nervous system
The nervous system is an organ system containing a network of specialized cells called neurons that coordinate the actions of an animal and transmit signals between different parts of its body. In most animals the nervous system consists of two parts, central and peripheral. The central nervous...
during development and are parts to the mechanism underlying the repulsive guidance of growth cones.