Combretastatin A-1
Encyclopedia
Combretastatin A-1 is a combretastatin
, a chemical compound belonging to stilbenoid class. It can be found in Combretum caffrum
, the Eastern Cape South African Bushwillow tree.
It is an antiangiogenic agent acting by destabilizing tubulin
, which induces cell apoptosis
of proliferating endothelial cells.
Combretastatin
The combretastatins are a class of natural stilbenoid natural phenols. A variety of different natural combretastatin molecules are present in the bark of Combretum caffrum, commonly known as South African Bush Willow...
, a chemical compound belonging to stilbenoid class. It can be found in Combretum caffrum
Combretum caffrum
Combretum caffrum is the Eastern Cape South African Bushwillow tree.-Biochemistry:In C. caffrum, combretastatins A-1, A-4 and B-1 can be found....
, the Eastern Cape South African Bushwillow tree.
It is an antiangiogenic agent acting by destabilizing tubulin
Tubulin
Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of α- and...
, which induces cell apoptosis
Apoptosis
Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...
of proliferating endothelial cells.