For more information about this drug and its actions, see combretastatin

Combretastatin

The combretastatins are a class of natural stilbenoid natural phenols. A variety of different natural combretastatin molecules are present in the bark of Combretum caffrum, commonly known as South African Bush Willow...

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Combretastatin A-4 phosphate (and its disodium salt) is a microtubule destabilizing drug, a type of vascular-targeting agent

Vascular-targeting agent

A vascular-targeting agent or vascular disrupting agent is a drug designed to damage the vasculature of cancer tumors causing central necrosis.VTAs can be small-molecule or ligand-based....

, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. It is a derivative of combretastatin

Combretastatin

The combretastatins are a class of natural stilbenoid natural phenols. A variety of different natural combretastatin molecules are present in the bark of Combretum caffrum, commonly known as South African Bush Willow...

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Combretastatin A-4 phosphate is a prodrug

Prodrug

A prodrug is a pharmacological substance administered in an inactive form. Once administered, the prodrug is metabolised in vivo into an active metabolite, a process termed bioactivation. The rationale behind the use of a prodrug is generally for absorption, distribution, metabolism, and...

. In vivo, it is dephosphorylated to its active metabolite, combretastatin A-4

Combretastatin A-4

Combretastatin A-4 is a combretastatin, a type of stilbenoid. It can be isolated from Combretum caffrum, the Eastern Cape South African Bushwillow tree.-Derivatives:...

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