Corticotropin releasing hormone receptor 1
Encyclopedia
Corticotropin releasing hormone receptor 1 (CRHR1) is a protein
, also known as CRF1, with the latter (CRF1) now being the IUPHAR-recommended name. In humans, CRF1 is encoded by the CRHR1 gene
.
, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.
CRF1 receptors in mice mediate ethanol enhancement of GABAergic synaptic transmission.
therapy in asthma
.
CRF1 receptor antagonists are being actively studied as possible treatments for depression and anxiety.
with Corticotropin-releasing hormone
and Urocortin
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
, also known as CRF1, with the latter (CRF1) now being the IUPHAR-recommended name. In humans, CRF1 is encoded by the CRHR1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
The corticotropin-releasing hormone receptor binds to corticotropin-releasing hormoneCorticotropin-releasing hormone
Corticotropin-releasing hormone , originally named corticotropin-releasing factor , and also called corticoliberin, is a polypeptide hormone and neurotransmitter involved in the stress response...
, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.
CRF1 receptors in mice mediate ethanol enhancement of GABAergic synaptic transmission.
Clinical significance
Variations in the CRHR1 gene is associated with enhanced response to inhaled corticosteroidCorticosteroid
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte...
therapy in asthma
Asthma
Asthma is the common chronic inflammatory disease of the airways characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm. Symptoms include wheezing, coughing, chest tightness, and shortness of breath...
.
CRF1 receptor antagonists are being actively studied as possible treatments for depression and anxiety.
Interactions
Corticotropin releasing hormone receptor 1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Corticotropin-releasing hormone
Corticotropin-releasing hormone
Corticotropin-releasing hormone , originally named corticotropin-releasing factor , and also called corticoliberin, is a polypeptide hormone and neurotransmitter involved in the stress response...
and Urocortin
Urocortin
Urocortin is a protein that in humans is encoded by the UCN gene.Urocortin is a potent anorexigenic peptide of 40 amino acids that induces fed-like motor activity when administered centrally or peripherally in fasted animals. Urocortin belongs to the corticotropin-releasing factor family that...
.
See also
- Corticotropin releasing hormone
- Corticotropin releasing hormone receptor
- Corticotropin releasing hormone antagonists
- AntalarminAntalarminAntalarmin is a drug that acts as a CRF-1 antagonist.Corticotropin-releasing factor , also known as Corticotropin-releasing hormone, is an endogenous peptide hormone released in response to various triggers such as chronic stress and drug addiction. This, then, triggers the release of corticotropin...
- PexacerfontPexacerfontPexacerfont is a drug developed by Bristol-Myers Squibb which acts as a CRF-1 antagonist.Corticotropin releasing factor , also known as Corticotropin releasing hormone, is an endogenous peptide hormone which is released in response to various triggers such as chronic stress...