Cryofibrinogenemia
Encyclopedia
Cryofibrinogenemia is defined by the presence of circulating cold insoluble complexes of fibrin
, fibrinogen
, fibronectin, and fibrin split products with albumin, immunoglobulins and plasma proteins that precipitate from the patient's plasma in the cold.
Fibrin
Fibrin is a fibrous, non-globular protein involved in the clotting of blood. It is a fibrillar protein that is polymerised to form a "mesh" that forms a hemostatic plug or clot over a wound site....
, fibrinogen
Fibrinogen
Fibrinogen is a soluble plasma glycoprotein, synthesised by the liver, that is converted by thrombin into fibrin during blood coagulation. This is achieved through processes in the coagulation cascade that activate the zymogen prothrombin to the serine protease thrombin, which is responsible for...
, fibronectin, and fibrin split products with albumin, immunoglobulins and plasma proteins that precipitate from the patient's plasma in the cold.