Cyclin-dependent kinase 7
Encyclopedia
Cell division protein kinase 7 is an enzyme
that in humans is encoded by the CDK7 gene
.
The protein encoded by this gene is a member of the cyclin-dependent protein kinase
(CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae
cdc28, and Schizosaccharomyces pombe
cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H
and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
with XPB
, Cyclin H
, P53
, Androgen receptor
, GTF2H1
, MNAT1
and SUPT5H
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the CDK7 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
The protein encoded by this gene is a member of the cyclin-dependent protein kinase
Cyclin-dependent kinase
thumb|350px|Schematic of the cell cycle. outer ring: I=[[Interphase]], M=[[Mitosis]]; inner ring: M=Mitosis; G1=[[G1 phase|Gap phase 1]]; S=[[S phase|Synthesis]]; G2=[[G2 phase|Gap phase 2]]...
(CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae
Saccharomyces cerevisiae
Saccharomyces cerevisiae is a species of yeast. It is perhaps the most useful yeast, having been instrumental to baking and brewing since ancient times. It is believed that it was originally isolated from the skin of grapes...
cdc28, and Schizosaccharomyces pombe
Schizosaccharomyces pombe
Schizosaccharomyces pombe, also called "fission yeast", is a species of yeast. It is used as a model organism in molecular and cell biology. It is a unicellular eukaryote, whose cells are rod-shaped. Cells typically measure 3 to 4 micrometres in diameter and 7 to 14 micrometres in length...
cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H
Cyclin H
Cyclin-H is a protein that in humans is encoded by the CCNH gene.-Interactions:Cyclin H has been shown to interact with P53, Cyclin-dependent kinase 7 and MNAT1.-Further reading:...
and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
Interactions
Cyclin-dependent kinase 7 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with XPB
XPB
XPB is an ATP dependent human DNA helicase that is a part of the TFIIH transcription factor complex.-Structure:The 3D structure of the archeael homologue of XPB has been solved by X-ray crystallography by Dr...
, Cyclin H
Cyclin H
Cyclin-H is a protein that in humans is encoded by the CCNH gene.-Interactions:Cyclin H has been shown to interact with P53, Cyclin-dependent kinase 7 and MNAT1.-Further reading:...
, P53
P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
, Androgen receptor
Androgen receptor
The androgen receptor , also known as NR3C4 , is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus...
, GTF2H1
GTF2H1
General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene.-Interactions:GTF2H1 has been shown to interact with E2F1, XPB, ERCC2, Estrogen receptor alpha, Cyclin-dependent kinase 7 and TCEA1....
, MNAT1
MNAT1
CDK-activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene.-Interactions:MNAT1 has been shown to interact with POU2F1, MTA1, Cyclin H, P53, Estrogen receptor alpha, MCM7 and Cyclin-dependent kinase 7....
and SUPT5H
SUPT5H
Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene.-Interactions:SUPT5H has been shown to interact with Cyclin-dependent kinase 7, PIN1, CDK9, HTATSF1, POLR2A, PRMT1 and Protein arginine methyltransferase 5....
.