Cyclin-dependent kinase inhibitor protein

A cyclin-dependent kinase inhibitor protein is a protein which inhibits cyclin-dependent kinase

Cyclin-dependent kinase

. Several function as tumor suppressor gene

Tumor suppressor gene

A tumor suppressor gene, or anti-oncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes.-Two-hit hypothesis:Unlike...

s. Cell cycle

Cell cycle

The cell cycle, or cell-division cycle, is the series of events that takes place in a cell leading to its division and duplication . In cells without a nucleus , the cell cycle occurs via a process termed binary fission...

progression is negatively controlled by cyclin-dependent kinases inhibitors (called CDIs, CKIs or CDKIs). CDIs are involved in cell cycle arrest

Restriction point

The restriction point is a G1 phase checkpoint in the cell cycle of animal cells. Prior to the restriction point, a cell exits the cell cycle if specific mitogenic and growth signals are absent. Cells that progress past the restriction point are committed to enter S phase, where DNA synthesis and...

at the G₁ phase

G1 phase

The G1 phase is a period in the cell cycle during interphase, before the S phase. For many cells, this phase is the major period of cell growth during its lifespan. During this stage new organelles are being synthesized, so the cell requires both structural proteins and enzymes, resulting in great...

Examples

Protein	Gene	Interacts with
p16 P16 (gene) Cyclin-dependent kinase inhibitor 2A, also known as multiple tumor suppressor 1 , is a tumor suppressor protein, that in humans is encoded by the CDKN2A gene...	CDKN2A CDKN2A CDKN2A can refer to:* P16 * p14arf...	Cyclin-dependent kinase 4 Cyclin-dependent kinase 4 Cyclin-dependent kinase 4 is part of the cyclin-dependent kinase family.It is regulated by Cyclin D.-Interactions:Cyclin-dependent kinase 4 has been shown to interact with SERTAD1, CDC37, CEBPA, PCNA, Cyclin D3, Cyclin D1, CDKN2C, MyoD, P16, CDKN2B, Drebrin-like and CDKN1B.-External links:... , Cyclin-dependent kinase 6 Cyclin-dependent kinase 6 Cell division protein kinase 6 is an enzyme that in humans is encoded by the CDK6 gene.It is regulated by Cyclin D.-Interactions:Cyclin-dependent kinase 6 has been shown to interact with CDKN2C, P16, PPM1B, Cyclin D3, Cyclin D1 and PPP2CA....
p15 CDKN2B Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 or p15INK4B is a protein that is encoded by the CDKN2B gene in humans.- Function :...	CDKN2B CDKN2B Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 or p15INK4B is a protein that is encoded by the CDKN2B gene in humans.- Function :...	Cyclin-dependent kinase 4 Cyclin-dependent kinase 4 Cyclin-dependent kinase 4 is part of the cyclin-dependent kinase family.It is regulated by Cyclin D.-Interactions:Cyclin-dependent kinase 4 has been shown to interact with SERTAD1, CDC37, CEBPA, PCNA, Cyclin D3, Cyclin D1, CDKN2C, MyoD, P16, CDKN2B, Drebrin-like and CDKN1B.-External links:...
p18 CDKN2C Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene.-Interactions:CDKN2C has been shown to interact with Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6.-Further reading:...	CDKN2C CDKN2C Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene.-Interactions:CDKN2C has been shown to interact with Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6.-Further reading:...	Cyclin-dependent kinase 4 Cyclin-dependent kinase 4 Cyclin-dependent kinase 4 is part of the cyclin-dependent kinase family.It is regulated by Cyclin D.-Interactions:Cyclin-dependent kinase 4 has been shown to interact with SERTAD1, CDC37, CEBPA, PCNA, Cyclin D3, Cyclin D1, CDKN2C, MyoD, P16, CDKN2B, Drebrin-like and CDKN1B.-External links:... , Cyclin-dependent kinase 6 Cyclin-dependent kinase 6 Cell division protein kinase 6 is an enzyme that in humans is encoded by the CDK6 gene.It is regulated by Cyclin D.-Interactions:Cyclin-dependent kinase 6 has been shown to interact with CDKN2C, P16, PPM1B, Cyclin D3, Cyclin D1 and PPP2CA....
p19 CDKN2D Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.Note, this protein should not be confused with p19-ARF or the human equivalent p14-ARF, which are alternative products of the CDKN2a gene....	CDKN2D CDKN2D Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.Note, this protein should not be confused with p19-ARF or the human equivalent p14-ARF, which are alternative products of the CDKN2a gene....	Cyclin-dependent kinase 4 Cyclin-dependent kinase 4 Cyclin-dependent kinase 4 is part of the cyclin-dependent kinase family.It is regulated by Cyclin D.-Interactions:Cyclin-dependent kinase 4 has been shown to interact with SERTAD1, CDC37, CEBPA, PCNA, Cyclin D3, Cyclin D1, CDKN2C, MyoD, P16, CDKN2B, Drebrin-like and CDKN1B.-External links:... , Cyclin-dependent kinase 6 Cyclin-dependent kinase 6 Cell division protein kinase 6 is an enzyme that in humans is encoded by the CDK6 gene.It is regulated by Cyclin D.-Interactions:Cyclin-dependent kinase 6 has been shown to interact with CDKN2C, P16, PPM1B, Cyclin D3, Cyclin D1 and PPP2CA....
p21 / WAF1 P21 p21 / WAF1 also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1 is a protein that in humans is encoded by the CDKN1A gene located on chromosome 6 .- Function :...	CDKN1A	Cyclin E1 Cyclin E1 G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.-Interactions:Cyclin E1 has been shown to interact with Retinoblastoma-like protein 2, Cdk1, CDC25A, Cyclin-dependent kinase 2, SMARCA4, CDKN1B, HERC5, CUL3 and P21.... /Cyclin-dependent kinase 2 Cyclin-dependent kinase 2 Cyclin-dependent kinase 2 also known as cell division protein kinase 2 is an enzyme that in humans is encoded by the CDK2 gene.-Function:...
p27 CDKN1B Cyclin-dependent kinase inhibitor 1B is an enzyme that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4...	CDKN1B CDKN1B Cyclin-dependent kinase inhibitor 1B is an enzyme that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4...	Cyclin D3/Cyclin-dependent kinase 4 Cyclin-dependent kinase 4 Cyclin-dependent kinase 4 is part of the cyclin-dependent kinase family.It is regulated by Cyclin D.-Interactions:Cyclin-dependent kinase 4 has been shown to interact with SERTAD1, CDC37, CEBPA, PCNA, Cyclin D3, Cyclin D1, CDKN2C, MyoD, P16, CDKN2B, Drebrin-like and CDKN1B.-External links:... , Cyclin E1 Cyclin E1 G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.-Interactions:Cyclin E1 has been shown to interact with Retinoblastoma-like protein 2, Cdk1, CDC25A, Cyclin-dependent kinase 2, SMARCA4, CDKN1B, HERC5, CUL3 and P21.... /Cyclin-dependent kinase 2 Cyclin-dependent kinase 2 Cyclin-dependent kinase 2 also known as cell division protein kinase 2 is an enzyme that in humans is encoded by the CDK2 gene.-Function:...
p57 Cyclin-dependent kinase inhibitor 1C Cyclin-dependent kinase inhibitor 1C , also known as CDKN1C, is protein which in humans is encoded by the CDKN1C imprinted gene.- Function :...	CDKN1C	Cyclin E1 Cyclin E1 G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.-Interactions:Cyclin E1 has been shown to interact with Retinoblastoma-like protein 2, Cdk1, CDC25A, Cyclin-dependent kinase 2, SMARCA4, CDKN1B, HERC5, CUL3 and P21.... /Cyclin-dependent kinase 2 Cyclin-dependent kinase 2 Cyclin-dependent kinase 2 also known as cell division protein kinase 2 is an enzyme that in humans is encoded by the CDK2 gene.-Function:...
	CDKN3 CDKN3 Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.-Interactions:CDKN3 has been shown to interact with Cyclin-dependent kinase 2, Cdk1 and MS4A3.-Further reading:...	Cyclin-dependent kinase 2 Cyclin-dependent kinase 2 Cyclin-dependent kinase 2 also known as cell division protein kinase 2 is an enzyme that in humans is encoded by the CDK2 gene.-Function:...

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