Cyrrhestica is a district of Greater Syria

Greater Syria

Greater Syria , also known simply as Syria, is a term that denotes a region in the Near East bordering the Eastern Mediterranean Sea or the Levant....

 which appears to have owed its name to the Macedonian occupation

Macedon

Macedonia or Macedon was an ancient kingdom, centered in the northeastern part of the Greek peninsula, bordered by Epirus to the west, Paeonia to the north, the region of Thrace to the east and Thessaly to the south....

 of the country. It lies between the plain of Antioch

Antioch

Antioch on the Orontes was an ancient city on the eastern side of the Orontes River. It is near the modern city of Antakya, Turkey.Founded near the end of the 4th century BC by Seleucus I Nicator, one of Alexander the Great's generals, Antioch eventually rivaled Alexandria as the chief city of the...

, and was bounded on the east by the Euphrates

Euphrates

The Euphrates is the longest and one of the most historically important rivers of Western Asia. Together with the Tigris, it is one of the two defining rivers of Mesopotamia...

, and on the west by Amanus and Commagene; to the south, it extended as far as the desert. This fertile, well-watered, and thickly peopled district occupied the right bank of the Euphrates, where the river inclines rather eastward of south. It was the scene of the campaign in which Ventidius defeated the Parthian

Parthian Empire

The Parthian Empire , also known as the Arsacid Empire , was a major Iranian political and cultural power in ancient Persia...

 Pacorus

Pacorus I of Parthia

Pacorus I of Parthia was the son of king Orodes II and queen Laodice of the Parthian Empire. It is possible that he was co-ruler with his father for at least part of his father's reign...

 and avenged Crassus and the Roman army which had fallen at Carrhae. Constantine I

Constantine I

Constantine the Great , also known as Constantine I or Saint Constantine, was Roman Emperor from 306 to 337. Well known for being the first Roman emperor to convert to Christianity, Constantine and co-Emperor Licinius issued the Edict of Milan in 313, which proclaimed religious tolerance of all...

 united it with Commagene under the name of Provincia Euphratensis. The chief towns of Cyrrhestica were Hierapolis Bambyce, Zeugma, Europus, Birtha

Birtha (Commagene)

Birtha was an ancient town on the east bank of the Euphrates, at the upper part of a reach of that river, which runs nearly north-south, and just below a sharp bend in the stream, where it follows that course after coming from a long reach flowing more from the west. This town has often been...

?, Beroea

Aleppo

Aleppo is the largest city in Syria and the capital of Aleppo Governorate, the most populous Syrian governorate. With an official population of 2,301,570 , expanding to over 2.5 million in the metropolitan area, it is also one of the largest cities in the Levant...

 (modern Aleppo), Batnae, and Cyrrhus

Cyrrhus, Syria

Cyrrhus, or Kyrros was a city in ancient Syria founded by Seleucus Nicator, one of Alexander the Great's generals. Other names for the city include Hagioupolis, Nebi Huri نبي حوري, Khoros . Its ruins are located in northern Syria, near the Turkish border. It lies about 70 km northwest of Aleppo...

.