D-amino acid dehydrogenase
Encyclopedia
D-amino-acid dehydrogenase (EC 1.4.99.1) is a bacteria
l enzyme that catalyses the oxidation of D-amino acids
into their corresponding oxoacids. It contains both flavin and nonheme iron
as cofactors. The enzyme has a very broad specificity and can act on most D-amino acids.
D-amino acid + H2O + acceptor <=> a 2-oxo acid + NH3 + reduced acceptor
This reaction is distinct from the oxidation reaction catalysed by D-amino acid oxidase
that uses oxygen
as a second substrate, as the dehydrogenase can use many different compounds as electron acceptors, with the physiological substrate being coenzyme Q
.
Bacteria
Bacteria are a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria have a wide range of shapes, ranging from spheres to rods and spirals...
l enzyme that catalyses the oxidation of D-amino acids
Amino acid
Amino acids are molecules containing an amine group, a carboxylic acid group and a side-chain that varies between different amino acids. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen...
into their corresponding oxoacids. It contains both flavin and nonheme iron
Iron
Iron is a chemical element with the symbol Fe and atomic number 26. It is a metal in the first transition series. It is the most common element forming the planet Earth as a whole, forming much of Earth's outer and inner core. It is the fourth most common element in the Earth's crust...
as cofactors. The enzyme has a very broad specificity and can act on most D-amino acids.
D-amino acid + H2O + acceptor <=> a 2-oxo acid + NH3 + reduced acceptor
This reaction is distinct from the oxidation reaction catalysed by D-amino acid oxidase
D-amino acid oxidase
D-amino acid oxidase is a peroxisomal enzyme containing FAD as cofactor that is expressed in a wide range of species from yeasts to human. It is not present in bacteria or in plants...
that uses oxygen
Oxygen
Oxygen is the element with atomic number 8 and represented by the symbol O. Its name derives from the Greek roots ὀξύς and -γενής , because at the time of naming, it was mistakenly thought that all acids required oxygen in their composition...
as a second substrate, as the dehydrogenase can use many different compounds as electron acceptors, with the physiological substrate being coenzyme Q
Coenzyme Q
Coenzyme Q10, also known as ubiquinone, ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10 , CoQ, Q10, or Q, is a 1,4-benzoquinone, where Q refers to the quinone chemical group, and 10 refers to the number of isoprenyl chemical subunits in its tail.This oil-soluble, vitamin-like substance...
.