DNA damage-binding protein 1 is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the DDB1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Function

This gene encodes the large subunit of DNA damage-binding protein

DNA damage-binding protein

DNA damage-binding protein is a protein complex that is responsible for repair of UV-damaged DNA. This complex is composed of two protein subunits, a large subunit DDB1 and a small subunit DDB2. This complex functions in nucleotide excision repair....

 which is a heterodimer composed of a large and a small (DDB2

DDB2

DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene.-Interactions:DDB2 has been shown to interact with CUL4A, CUL4B and DDB1.-External Links:* -Further reading:...

) subunit. This protein functions in nucleotide excision repair

Nucleotide excision repair

Nucleotide excision repair is a DNA repair mechanism. DNA constantly requires repair due to damage that can occur to bases from a vast variety of sources including chemicals, radiation and other mutagens...

. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum

Xeroderma pigmentosum

Xeroderma pigmentosum, or XP, is an autosomal recessive genetic disorder of DNA repair in which the ability to repair damage caused by ultraviolet light is deficient. In extreme cases, all exposure to sunlight must be forbidden, no matter how small. Multiple basal cell carcinomas and other skin...

 complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform macular dystrophy

Vitelliform macular dystrophy

Vitelliform macular dystrophy or vitelliform dystrophy is a genetic eye disorder that can cause progressive vision loss. This disorder affects the retina, specifically cells in a small area near the center of the retina called the macula...

 is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.

Interactions

DDB1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with Transcription initiation protein SPT3 homolog

Transcription initiation protein SPT3 homolog

Transcription initiation protein SPT3 homolog is a protein that in humans is encoded by the SUPT3H gene.-Interactions:Transcription initiation protein SPT3 homolog has been shown to interact with GCN5L2, TAF6L, TADA3L, TAF5L, SF3B3, SUPT7L, Myc, TAF9, Transformation/transcription domain-associated...

, GCN5L2

GCN5L2

Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene.-Interactions:GCN5L2 has been shown to interact with Ku70, TAF9, Transcription initiation protein SPT3 homolog, TADA2L, Ku80 and DDB1.-External links:...

, DDB2

DDB2

DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene.-Interactions:DDB2 has been shown to interact with CUL4A, CUL4B and DDB1.-External Links:* -Further reading:...

, CUL4A

CUL4A

Cullin-4A is a protein that in humans is encoded by the CUL4A gene.-Interactions:CUL4A has been shown to interact with Merlin, DDB2, CAND1, RBX1, DDB1 and P21.-Further reading:...

, CUL4B

CUL4B

Cullin-4B is a protein that in humans is encoded by the CUL4B gene.-Interactions:CUL4B has been shown to interact with DDB2, CAND1 and DDB1.-Further reading:...

 and P21

P21

p21 / WAF1 also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1 is a protein that in humans is encoded by the CDKN1A gene located on chromosome 6 .- Function :...

.

Further reading