DLX5
Encyclopedia
Homeobox
protein DLX-5 is a protein
that in humans is encoded by the DLX5 gene
.
transcription factor gene family similar to the Drosophila
distal-less (Dll) gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.
.
with DLX2
, MSX1
and MSX2
.
Homeobox
A homeobox is a DNA sequence found within genes that are involved in the regulation of patterns of anatomical development in animals, fungi and plants.- Discovery :...
protein DLX-5 is a protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the DLX5 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
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Function
This gene encodes a member of a homeoboxHomeobox
A homeobox is a DNA sequence found within genes that are involved in the regulation of patterns of anatomical development in animals, fungi and plants.- Discovery :...
transcription factor gene family similar to the Drosophila
Drosophila
Drosophila is a genus of small flies, belonging to the family Drosophilidae, whose members are often called "fruit flies" or more appropriately pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit...
distal-less (Dll) gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.
Genetics
Mutations in the DLX5 gene have been shown to be involved in the hand and foot malformation syndromeEctrodactyly
Ectrodactyly, sometimes referred to as the “Lobster-Claw Syndrome” involves the deficiency or absence of one or more central digits of the hand or foot and is also known as split hand/split foot malformation...
.
Interactions
DLX5 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with DLX2
DLX2
Homeobox protein DLX-2 is a protein that in humans is encoded by the DLX2 gene.-Interactions:DLX2 has been shown to interact with DLX5, MSX1 and Msh homeobox 2.-Further reading:...
, MSX1
MSX1
Msh homeobox 1, also known as MSX1, is a protein that in humans is encoded by the MSX1 gene. MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue that produces both TSHß- and a-subunits and...
and MSX2
Msh homeobox 2
Homeobox protein MSX-2 is a protein that in humans is encoded by the MSX2 gene.-Interactions:Msh homeobox 2 has been shown to interact with DLX5, DLX2 and MSX1.-Further reading:- External links :*...
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