David States
Encyclopedia
David J. States M.D., Ph.D. is a Professor of Human Genetics at the University of Michigan
. His research group is using computational methods to understand the human genome and how it relates to the human proteome
. He is the Director of the Michigan NIH Bioinformatics Training Program and a Senior Scientist in the National Center for Integrative Biomedical Informatics.
Dr. States earned his BA ('75), MD ('83) and PhD ('83) degrees at Harvard University
. He was a Staff Scientist at the National Magnet Laboratory at MIT and a resident in internal medicine at UCSD Medical Center. He then moved to the NIH as a Clinical Associate and Senior Staff Fellow where he joined the National Center for Biotechnology Information (NCBI). While at NCBI, he and Warren Gish enhanced BLAST
, one of the most widely used programs in bioinformatics [4]. In 1992, Dr. States was recruited to Washington University as Director of the Institute for Biomedical Computing, and in 2001, he moved to the University of Michigan to establish the University of Michigan Bioinformatics Program. He was a member of the founding Board of Directors and Treasurer of the International Society for Computational Biology and Chair of the 1996 and 2005 Intelligent Systems for Molecular Biology Conferences.
Dr. States is also known for his work in nuclear magnetic resonance
where he developed pure absorption phase multi-dimensional spectroscopy, a technique now widely used in protein structure determination. Dr. States also contributed to computational biophysics as an author of the CHARMM
molecular dynamics simulation program. He combined NMR spectroscopy and modeling to demonstrate for the first time the presence of native-like structure in the folding intermediates of bovine pancreatic trypsin inhibitor[1-2] and the first demonstration of a conformationally trapped folding intermediate [3].
University of Michigan
The University of Michigan is a public research university located in Ann Arbor, Michigan in the United States. It is the state's oldest university and the flagship campus of the University of Michigan...
. His research group is using computational methods to understand the human genome and how it relates to the human proteome
Proteome
The proteome is the entire set of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the set of expressed proteins in a given type of cells or an organism at a given time under defined conditions. The term is a portmanteau of proteins and genome.The term has been...
. He is the Director of the Michigan NIH Bioinformatics Training Program and a Senior Scientist in the National Center for Integrative Biomedical Informatics.
Dr. States earned his BA ('75), MD ('83) and PhD ('83) degrees at Harvard University
Harvard University
Harvard University is a private Ivy League university located in Cambridge, Massachusetts, United States, established in 1636 by the Massachusetts legislature. Harvard is the oldest institution of higher learning in the United States and the first corporation chartered in the country...
. He was a Staff Scientist at the National Magnet Laboratory at MIT and a resident in internal medicine at UCSD Medical Center. He then moved to the NIH as a Clinical Associate and Senior Staff Fellow where he joined the National Center for Biotechnology Information (NCBI). While at NCBI, he and Warren Gish enhanced BLAST
BLAST
In bioinformatics, Basic Local Alignment Search Tool, or BLAST, is an algorithm for comparing primary biological sequence information, such as the amino-acid sequences of different proteins or the nucleotides of DNA sequences...
, one of the most widely used programs in bioinformatics [4]. In 1992, Dr. States was recruited to Washington University as Director of the Institute for Biomedical Computing, and in 2001, he moved to the University of Michigan to establish the University of Michigan Bioinformatics Program. He was a member of the founding Board of Directors and Treasurer of the International Society for Computational Biology and Chair of the 1996 and 2005 Intelligent Systems for Molecular Biology Conferences.
Dr. States is also known for his work in nuclear magnetic resonance
Nuclear magnetic resonance
Nuclear magnetic resonance is a physical phenomenon in which magnetic nuclei in a magnetic field absorb and re-emit electromagnetic radiation...
where he developed pure absorption phase multi-dimensional spectroscopy, a technique now widely used in protein structure determination. Dr. States also contributed to computational biophysics as an author of the CHARMM
CHARMM
CHARMM is the name of a widely used set of force fields for molecular dynamics as well as the name for the molecular dynamics simulation and analysis package associated with them...
molecular dynamics simulation program. He combined NMR spectroscopy and modeling to demonstrate for the first time the presence of native-like structure in the folding intermediates of bovine pancreatic trypsin inhibitor[1-2] and the first demonstration of a conformationally trapped folding intermediate [3].