De novo - AbsoluteAstronomy.com

In general usage, de novo is a Latin expression meaning "from the beginning," "afresh," "anew," "beginning again." It is used in:

De novo transcriptome assembly
De novo transcriptome assembly
De novo transcriptome assembly is the method of creating a transcriptome without the aid of a reference genome.- Introduction :Before de novo transcriptome assembly, transcriptome information was only readily available for a handful of model organisms utilized by the international scientific...

, the method of creating a transcriptome without a reference genome
De novo synthesis
De novo synthesis
De novo synthesis refers to the synthesis of complex molecules from simple molecules such as sugars or amino acids, as opposed to their being recycled after partial degradation. For example, nucleotides are not needed in the diet as they can be constructed from small precursor molecules such as...

of complex molecules from simple molecules in biochemistry
Trial de novo
Trial de novo
In law, the expression trial de novo means a "new trial" by a different tribunal...

, or a new trial in the legal system
In Appeals Court Standard of Review, the Appeals Court, based upon Rules Of Appellant Procedure, must review non-jury cases de novo to determine if the Trial Judge came to a reasonable conclusion. In Federal and most United States courts that rule is handled under Rule 13 of the Court rules. In issues of witness credibility, on de novo review, the determination of the Trial Court is given great weight. Conclusions of law are reviewed de novo with no presumption of correctness.
De novo bank, a state bank
State bank
A state bank is generally a financial institution that is chartered by a state. It differs from a reserve bank in that it does not necessarily control monetary policy , but instead usually offers only retail and commercial services.A state bank that has been in operation for five years or less is...

that has been in operation for five years or less
In bioinformatics
Bioinformatics
Bioinformatics is the application of computer science and information technology to the field of biology and medicine. Bioinformatics deals with algorithms, databases and information systems, web technologies, artificial intelligence and soft computing, information and computation theory, software...

, de novo is a form of sequencing
Sequencing
In genetics and biochemistry, sequencing means to determine the primary structure of an unbranched biopolymer...

, as in "de novo peptide sequencing
De novo protein structure prediction
In computational biology, de novo protein structure prediction is the task of estimating a protein's tertiary structure from its sequence alone. The problem is very difficult and has occupied leading scientists for decades. Research has focused in three areas: alternate lower-resolution...

." De novo may also be a term used to define methods for making predictions about biological features using only a computational model without extrinsic comparison to existing data. In this context, it may be sometimes interchangeable with the Latin term ab initio
Ab initio
ab initio is a Latin term used in English, meaning from the beginning.ab initio may also refer to:* Ab Initio , a leading ETL Tool Software Company in the field of Data Warehousing.* ab initio quantum chemistry methods...

.
De novo mutation
Mutation
In molecular biology and genetics, mutations are changes in a genomic sequence: the DNA sequence of a cell's genome or the DNA or RNA sequence of a virus. They can be defined as sudden and spontaneous changes in the cell. Mutations are caused by radiation, viruses, transposons and mutagenic...

, a genetic mutation that neither parent possessed nor transmitted.
In financial terminology, numbers reported by newly founded companies (especially the financial services industry) are qualified as "de novo," to distinguish them from older companies. For example, "growth de novo" means growth of newly started companies.
In the context of marketing and advertising, de novo means "again, but in a different way" and is linked to guerrilla and grass roots marketing campaigns.
Synonym of ex novo

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