Dentin sialophosphoprotein is the only protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 produced uniquely by odontoblast

Odontoblast

In vertebrates, an odontoblast is a biological cell of neural crest origin that is part of the outer surface of the dental pulp, and whose biological function is dentinogenesis, which is the creation of dentin, the substance under the tooth enamel....

s, the cells that produce tooth

Tooth

Teeth are small, calcified, whitish structures found in the jaws of many vertebrates that are used to break down food. Some animals, particularly carnivores, also use teeth for hunting or for defensive purposes. The roots of teeth are embedded in the Mandible bone or the Maxillary bone and are...

 dentin

Dentin

Dentine is a calcified tissue of the body, and along with enamel, cementum, and pulp is one of the four major components of teeth. Usually, it is covered by enamel on the crown and cementum on the root and surrounds the entire pulp...

. It is a non-collagen

Collagen

Collagen is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of mammals. It is the main component of connective tissue, and is the most abundant protein in mammals, making up about 25% to 35% of the whole-body protein content...

ous SIBLING

SIBLING proteins

The family of non-collagenous proteins known as SIBLING proteins, standing for small integrin-binding ligand, N-linked glycoprotein, included proteins that exist in the extracellular matrix of bone and dentin and are believed to play key roles in the mineralization of these two substances.The...

 protein that is later cleaved into three functional proteins: dentin phosphoprotein

Dentin phosphoprotein

Dentin phophoprotein, or phosphophoryn, is one of three proteins formed from dentin sialophosphoprotein and is important in the regulation of mineralization of dentin....

 (also known as phosphophoryn), taken from the C-terminal end, dentin sialoprotein

Dentin sialoprotein

Dentin sialoprotein is a protein found in teeth. It is one of the two proteins produced by the segmentation of dentin sialophosphoprotein. Dentin sialoprotein can be found in the dentin immediately subjacent to cellular cementum, but not subjacent to acellular fibrous cementum....

 from the N-terminal end, and dentin glycoprotein from the middle of the molecule. Their distribution in the collagen

Collagen

Collagen is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of mammals. It is the main component of connective tissue, and is the most abundant protein in mammals, making up about 25% to 35% of the whole-body protein content...

 matrix of the forming dentin suggests these proteins play an important role in the regulation of mineral deposition. Additional evidence for this correlation is phenotypically manifested in patients with mutant forms of dentin sialophosphoprotein. Such patients suffer dental anomalies including type III dentinogenesis imperfecta

Dentinogenesis imperfecta

Dentinogenesis imperfecta is a genetic disorder of tooth development. This condition causes teeth to be discolored and translucent. Teeth are also weaker than normal, making them prone to rapid wear, breakage, and loss. These problems can affect both primary teeth and permanent teeth...

.

It is coded for by a gene of the same name.