Derivative chromosome
Encyclopedia
A derivative chromosome (der) is a structurally rearranged chromosome
generated either by a rearrangement involving two or more chromosomes or by multiple aberrations within a single chromosome (e.g. an inversion and a deletion of the same chromosome, or deletions in both arms of a single chromosome).http://ghr.nlm.nih.gov/ghr/glossary/derivativechromosome The term always refers to the chromosome that has an intact centromere.
Derivative chromosomes are designated by the abbreviation der when used to describe a Karyotype
. The derivative chromosome must be specified in parentheses followed by all aberrations involved in this derivative chromosome. The aberrations must be listed from pter to qter and not be separated by a comma.
For example, 46,XY,der(4)t(4;8)(p16;q22)t(4;9)(q31;q31) would refer to a derivative chromosome 4 which is the result of a translocation between the short arm of chromosome 4 at band 16 and the long arm of chromosome 8 at band 22, and a translocation between the long arm of chromosome 4 at band 31 and the long arm of chromosome 9 at band 31.
Derivative chromosomes and other abnormalities could be drawn online using CyDAS online tools (Hiller B, Bradtke J, Balz H and Rieder H (2004): "CyDAS Online Analysis Site", http://www.cydas.org/OnlineAnalysis/)
Chromosome
A chromosome is an organized structure of DNA and protein found in cells. It is a single piece of coiled DNA containing many genes, regulatory elements and other nucleotide sequences. Chromosomes also contain DNA-bound proteins, which serve to package the DNA and control its functions.Chromosomes...
generated either by a rearrangement involving two or more chromosomes or by multiple aberrations within a single chromosome (e.g. an inversion and a deletion of the same chromosome, or deletions in both arms of a single chromosome).http://ghr.nlm.nih.gov/ghr/glossary/derivativechromosome The term always refers to the chromosome that has an intact centromere.
Derivative chromosomes are designated by the abbreviation der when used to describe a Karyotype
Karyotype
A karyotype is the number and appearance of chromosomes in the nucleus of an eukaryotic cell. The term is also used for the complete set of chromosomes in a species, or an individual organism.p28...
. The derivative chromosome must be specified in parentheses followed by all aberrations involved in this derivative chromosome. The aberrations must be listed from pter to qter and not be separated by a comma.
For example, 46,XY,der(4)t(4;8)(p16;q22)t(4;9)(q31;q31) would refer to a derivative chromosome 4 which is the result of a translocation between the short arm of chromosome 4 at band 16 and the long arm of chromosome 8 at band 22, and a translocation between the long arm of chromosome 4 at band 31 and the long arm of chromosome 9 at band 31.
Derivative chromosomes and other abnormalities could be drawn online using CyDAS online tools (Hiller B, Bradtke J, Balz H and Rieder H (2004): "CyDAS Online Analysis Site", http://www.cydas.org/OnlineAnalysis/)