The diagonal band of Broca forms the medial margin of the anterior perforated substance

Anterior perforated substance

The anterior perforated substance is an irregularly quadrilateral area in front of the optic tract and behind the olfactory trigone, from which it is separated by the fissure prima; medially and in front, it is continuous with the subcallosal gyrus; it is bounded laterally by the lateral stria of...

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Contents

It consists of fibers that are said to arise in the parolfactory area, the gyrus subcallosus and the anterior perforated substance

Anterior perforated substance

The anterior perforated substance is an irregularly quadrilateral area in front of the optic tract and behind the olfactory trigone, from which it is separated by the fissure prima; medially and in front, it is continuous with the subcallosal gyrus; it is bounded laterally by the lateral stria of...

, and course backward in the longitudinal striae to the dentate gyrus

Dentate gyrus

The dentate gyrus is part of the hippocampal formation. It is thought to contribute to new memories as well as other functional roles. It is notable as being one of a select few brain structures currently known to have high rates of neurogenesis in adult rats, .The dentate gyrus cells receive...

 and the hippocampal region.

This is a cholinergic

Cholinergic

The word choline generally refers to the various quaternary ammonium salts containing the N,N,N-trimethylethanolammonium cation. Found in most animal tissues, choline is a primary component of the neurotransmitter acetylcholine and functions with inositol as a basic constituent of lecithin...

 bundle of nerve fibers posterior to the anterior perforated substance

Anterior perforated substance

The anterior perforated substance is an irregularly quadrilateral area in front of the optic tract and behind the olfactory trigone, from which it is separated by the fissure prima; medially and in front, it is continuous with the subcallosal gyrus; it is bounded laterally by the lateral stria of...

. It interconnects the paraterminal gyrus

Paraterminal gyrus

The paraterminal gyrus is a narrow lamina on the medial surface of the hemisphere in front of the lamina terminalis, behind the parolfactory area, and below the rostrum of the corpus callosum. It is continuous around the genu of the corpus callosum with the supracallosal gyrus....

 in the septal area with the hippocampus

Hippocampus

The hippocampus is a major component of the brains of humans and other vertebrates. It belongs to the limbic system and plays important roles in the consolidation of information from short-term memory to long-term memory and spatial navigation. Humans and other mammals have two hippocampi, one in...

 and lateral olfactory area.

Function

Along with the septum pellucidum

Septum pellucidum

The septum pellucidum , and not to be confused with the medial septum, is a thin, triangular, vertical membrane separating the anterior horns of the left and right lateral ventricles of the brain...

 and medial septal nucleus

Medial septal nucleus

The medial septal nucleus is one of the septal nuclei. Neurons in this nucleus give rise to the bulk of efferents from the septal nuclei. A major projection from the medial septal nucleus terminates in the hippocampal formation....

, the diagonal band of Broca is believed to be involved in the generation of theta waves in the hippocampus

Hippocampus

The hippocampus is a major component of the brains of humans and other vertebrates. It belongs to the limbic system and plays important roles in the consolidation of information from short-term memory to long-term memory and spatial navigation. Humans and other mammals have two hippocampi, one in...

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Its behavior can be altered by nerve growth factor

Nerve growth factor

Nerve growth factor is a small secreted protein that is important for the growth, maintenance, and survival of certain target neurons . It also functions as a signaling molecule. It is perhaps the prototypical growth factor, in that it is one of the first to be described...

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