Digoxin Immune Fab
Encyclopedia
Digoxin Immune Fab is the generic name for an antidote for overdose of digitalis
. It is made from immunoglobulin fragments from sheep who have already been immunized with a digoxin derivative, digoxindicarboxymethoxylamine (DDMA). Its brand names include Digibind and DigiFab, with the former manufactured by GlaxoSmithKline
and the latter manufactured by BTG plc.
s have been noted, the patient must be closely monitored for anaphylactic shock, and anyone allergic to sheep protein, papain
, bromelain
, or papaya
extracts (papain is used to cleave the antibody into Fab and Fc fragments) should not use Digoxin Immune Fab (Ovine). Because it is relatively new, no drug interaction studies have been performed yet.
Digitalis
Digitalis is a genus of about 20 species of herbaceous perennials, shrubs, and biennials that are commonly called foxgloves. This genus was traditionally placed in the figwort family Scrophulariaceae, but recent reviews of phylogenetic research have placed it in the much enlarged family...
. It is made from immunoglobulin fragments from sheep who have already been immunized with a digoxin derivative, digoxindicarboxymethoxylamine (DDMA). Its brand names include Digibind and DigiFab, with the former manufactured by GlaxoSmithKline
GlaxoSmithKline
GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...
and the latter manufactured by BTG plc.
Pharmacology
It works by binding to the digoxin, rendering them unable to bind to their action sites on target cells. The complexes accumulate in the blood and are expelled by the kidney.Contraindications
Although no contraindicationContraindication
In medicine, a contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment.Some contraindications are absolute, meaning that there are no reasonable circumstances for undertaking a course of action...
s have been noted, the patient must be closely monitored for anaphylactic shock, and anyone allergic to sheep protein, papain
Papain
Papain, also known as papaya proteinase I, is a cysteine protease enzyme present in papaya and mountain papaya .-Papain family:...
, bromelain
Bromelain
Bromelain is a pineapple extract thought to be effective for reducing swelling , especially of the nose and sinuses, after surgery or injury. It may also be used for a variety of other effects that remain scientifically unconfirmed and not authorized by regulatory authorities like the Food and Drug...
, or papaya
Papaya
The papaya , papaw, or pawpaw is the fruit of the plant Carica papaya, the sole species in the genus Carica of the plant family Caricaceae...
extracts (papain is used to cleave the antibody into Fab and Fc fragments) should not use Digoxin Immune Fab (Ovine). Because it is relatively new, no drug interaction studies have been performed yet.