Diphenylmethylpiperazine
Encyclopedia
1-piperazine, also known as benzhydrylpiperazine, is a chemical compound
and piperazine
derivative. It features a piperazine
ring
with a benzhydryl (diphenylmethyl) group
bound to one of the nitrogen
s.
A number of diphenylmethylpiperazine derivatives are drug
s, including:
Amperozide
, BRL-15,572, chlorbenzoxamine
, DBL-583
, GBR-12,935, lidoflazine
, and vanoxerine
are diphenylalkylpiperazines with extended side chain
s and/or other modifications.
Chemical compound
A chemical compound is a pure chemical substance consisting of two or more different chemical elements that can be separated into simpler substances by chemical reactions. Chemical compounds have a unique and defined chemical structure; they consist of a fixed ratio of atoms that are held together...
and piperazine
Piperazine
Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Piperazine exists as small alkaline deliquescent crystals with a saline taste....
derivative. It features a piperazine
Piperazine
Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Piperazine exists as small alkaline deliquescent crystals with a saline taste....
ring
Functional group
In organic chemistry, functional groups are specific groups of atoms within molecules that are responsible for the characteristic chemical reactions of those molecules. The same functional group will undergo the same or similar chemical reaction regardless of the size of the molecule it is a part of...
with a benzhydryl (diphenylmethyl) group
Functional group
In organic chemistry, functional groups are specific groups of atoms within molecules that are responsible for the characteristic chemical reactions of those molecules. The same functional group will undergo the same or similar chemical reaction regardless of the size of the molecule it is a part of...
bound to one of the nitrogen
Nitrogen
Nitrogen is a chemical element that has the symbol N, atomic number of 7 and atomic mass 14.00674 u. Elemental nitrogen is a colorless, odorless, tasteless, and mostly inert diatomic gas at standard conditions, constituting 78.08% by volume of Earth's atmosphere...
s.
A number of diphenylmethylpiperazine derivatives are drug
Drug
A drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. There is no single, precise definition, as there are different meanings in drug control law, government regulations, medicine, and colloquial usage.In pharmacology, a...
s, including:
- Pharmaceuticals
- AlmitrineAlmitrineAlmitrine is a diphenylmethylpiperazine derivative classified as a respiratory stimulant by the ATC. It enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies...
- Respiratory stimulant - BuclizineBuclizineBuclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclozine....
- Antihistamine - CetirizineCetirizineCetirizine , a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria.-Availability:...
- Antihistamine - ChlorcyclizineChlorcyclizineChlorcyclizine is a first-generation antihistamine of the phenylpiperazine class marketed in the United States and certain other countries. It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic...
- Antihistamine - CinnarizineCinnarizineCinnarizine is an antihistamine which is mainly used for the control of nausea and vomiting due to motion sickness. Cinnarizine was first synthesized by Janssen Pharmaceutica in 1955...
- Antihistamine - ClocinizineClocinizineClocinizine is an first-generation antihistamine of the phenylpiperazine class....
- Antihistamine - CyclizineCyclizineCyclizine is an antihistamine drug used to treat nausea, vomiting and dizziness associated with motion sickness, vertigo and post-operatively following administration of general anaesthesia and opioids.-Indications:...
- Antihistamine - DotarizineDotarizineDotarizine is a drug used in the treatment of migraine, which acts as a calcium channel blocker, and also as an antagonist at the 5HT2A receptor, and to a lesser extent at the 5HT1A and 5HT2C receptors. The anti-migraine action is thought to be due to its action as a vasodilator, but it also has...
- Antimigraine - HydroxyzineHydroxyzineHydroxyzine is a first-generation antihistamine of the diphenylmethane and piperazine classes. It was first synthesized by Union Chimique Belge in 1956 and was marketed by Pfizer in the United States later the same year, and is still in widespread use today....
- Antihistamine - MeclozineMeclozineMeclozine is an antihistamine considered to be an antiemetic. It is sold under the brand names Bonine, Bonamine, Antivert, Postafen, Sea Legs, and Dramamine . Emesafene is a combination of meclozine and pyridoxine...
- Antihistamine - OxatomideOxatomideOxatomide is a first-generation antihistamine of the phenylpiperazine class. It was discovered at Janssen Pharmaceutica in 1975. Oxatomide lacks any anticholinergic effects. In addition to its H1 receptor antagonism, it also possesses antiserotonergic actions....
- Antihistamine
- Almitrine
- Research chemicals
- BW373U86BW373U86BW373U86 is an opioid analgesic drug used in scientific research.BW373U86 is a selective agonist for the δ-opioid receptor, with approximately 15x stronger affinity for the δ-opioid than the μ-opioid receptor...
- Opioid analgesic - DPI-221DPI-221DPI-221 is a drug which is used in scientific research. It is a highly selective agonist for the δ-opioid receptor which produces less convulsions than most drugs from this family....
- Opioid analgesic - DPI-287DPI-287DPI-287 is a drug that is used in scientific research. It is a highly selective agonist for the δ-opioid receptor, which produces less convulsions than most drugs from this family. It has antidepressant effects....
- Opioid analgesic - DPI-3290DPI-3290DPI-3290 was discoverd by Delta Pharmacutical and is a drug that is used in scientific research. It is a potent analgesic drug, which produces little respiratory depression....
- Opioid analgesic - SNC-80SNC-80SNC-80 is an opioid analgesic drug used in scientific research. It was invented in 1994.SNC-80 was the first non-peptide drug developed that is a highly selective agonist for the δ-opioid receptor....
- Opioid analgesic
- BW373U86
Amperozide
Amperozide
Amperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT2A receptor. It does not block dopamine receptors as with most antipsychotic drugs, but does inhibit dopamine release, and alters the firing pattern of dopaminergic neurons...
, BRL-15,572, chlorbenzoxamine
Chlorbenzoxamine
Chlorbenzoxamine is a drug used for functional gastrointestinal disorders....
, DBL-583
DBL-583
DBL-583 is a selective dopamine reuptake inhibitor of the piperazine chemical class. It is the decanoate ester of vanoxerine. DBL-583 breaks down very slowly in the body, lasting for up to a month after a single injection....
, GBR-12,935, lidoflazine
Lidoflazine
Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action. Lidoflazine was discovered at Janssen Pharmaceutica in 1964.-Solubility at room temperature:Extracted from -References:...
, and vanoxerine
Vanoxerine
Vanoxerine is a piperazine derivative which is a potent and selective DRI. GBR-12909 binds to the target site on the DAT ~ 500 times more strongly than cocaine, but simultaneously inhibits the release of dopamine...
are diphenylalkylpiperazines with extended side chain
Side chain
In organic chemistry and biochemistry, a side chain is a chemical group that is attached to a core part of the molecule called "main chain" or backbone. The placeholder R is often used as a generic placeholder for alkyl group side chains in chemical structure diagrams. To indicate other non-carbon...
s and/or other modifications.
See also
- PhenylpiperazinePhenylpiperazine1-Phenylpiperazine is a simple chemical compound featuring a phenyl group bound to a piperazine ring. The suffix '-piprazole' is sometimes used in the names of drugs to indicate they belong to this class....
- Pyrimidinylpiperazine
- BenzylpiperazineBenzylpiperazineBenzylpiperazine is a recreational drug with euphoric, stimulant properties. The effects produced by BZP are comparable to those produced by amphetamine. Adverse effects have been reported following its use including acute psychosis, renal toxicity, and seizures...