Dishevelled
Encyclopedia
Dishevelled is a family of protein
s involved in canonical and non-canonical Wnt signalling pathways. Dsh is a cytoplasmic
phosphoprotein
that acts directly downstream of frizzled
receptors. It takes its name from its initial discovery in flies
, where a mutation in the dishevelled gene was observed to cause improper orientation of body and wing hairs.
Dishevelled plays important roles in both the embryo and the adult, ranging from cellular differentiation
and cell polarity to social behavior.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
s involved in canonical and non-canonical Wnt signalling pathways. Dsh is a cytoplasmic
Cytoplasm
The cytoplasm is a small gel-like substance residing between the cell membrane holding all the cell's internal sub-structures , except for the nucleus. All the contents of the cells of prokaryote organisms are contained within the cytoplasm...
phosphoprotein
Phosphoprotein
Phosphoproteins are proteins that are physically bonded to a substance containing phosphoric acid . This category of organic molecules includes Fc receptors, Ulks, Calcineurins, K chips, and urocortins....
that acts directly downstream of frizzled
Frizzled
Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol.-Species distribution:...
receptors. It takes its name from its initial discovery in flies
Drosophila melanogaster
Drosophila melanogaster is a species of Diptera, or the order of flies, in the family Drosophilidae. The species is known generally as the common fruit fly or vinegar fly. Starting from Charles W...
, where a mutation in the dishevelled gene was observed to cause improper orientation of body and wing hairs.
Dishevelled plays important roles in both the embryo and the adult, ranging from cellular differentiation
Cellular differentiation
In developmental biology, cellular differentiation is the process by which a less specialized cell becomes a more specialized cell type. Differentiation occurs numerous times during the development of a multicellular organism as the organism changes from a simple zygote to a complex system of...
and cell polarity to social behavior.
Members
There are three human genes that encode dishevelled proteins:- DVL1DVL1Segment polarity protein dishevelled homolog DVL-1 is a protein that in humans is encoded by the DVL1 gene.-Interactions:DVL1 has been shown to interact with DVL3, EPS8, AXIN1 and Mothers against decapentaplegic homolog 3.-External links:...
- DVL2DVL2Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.-Interactions:DVL2 has been shown to interact with Zinc finger protein 165, DAB2 and Arrestin beta 1.-Further reading:...
- DVL3DVL3Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene.-Interactions:DVL3 has been shown to interact with DAB2, DVL1 and PRPF3.-Further reading:...