Ditran
Encyclopedia
Ditran is an anticholinergic
drug mixture, related to the chemical warfare agent 3-Quinuclidinyl benzilate
(QNB).
Ditran is composed of a mixture of 70% 1-ethyl- 2-pyrrolidinylmethyl- alpha- phenylcyclopentylglycolate and 30% 1-ethyl- 3-piperidyl- alpha- phenylcyclopentylglycolate. These compounds are structural isomers and have very similar pharmacological properties. The piperidine compound is the more potent of the two and the reason the mixture was used was because of ease of manufacture, however it is also possible to make the piperidine compound in its pure form, so there were ultimately two forms of Ditran used in research, the original 70/30 mix, and "Ditran-B", the pure piperidine compound. Ditran was developed during chemical weapons research in an attempt to produce non-lethal incapacitating agents, similar to QNB itself. The ditran mixture is more potent as an anticholinergic than the piperidyl benzilate drugs such as N- methyl- 3 -piperidyl benzilate, but is less potent than QNB.
There has been a modest amount of scientific research using this mixture, but most modern research using these kind of anticholinergic drugs uses N- methyl- 3- piperidyl benzilate due to its wider availability.
Anticholinergic
An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. An example of an anticholinergic is dicycloverine, and the classic example is atropine....
drug mixture, related to the chemical warfare agent 3-Quinuclidinyl benzilate
3-Quinuclidinyl benzilate
3-quinuclidinyl benzilate , IUPAC name 1-azabicyclo[2.2.2]Oct-3-yl α-hydroxy-α-phenylbenzeneacetate, is an odorless military incapacitating agent. Its NATO code is BZ...
(QNB).
Ditran is composed of a mixture of 70% 1-ethyl- 2-pyrrolidinylmethyl- alpha- phenylcyclopentylglycolate and 30% 1-ethyl- 3-piperidyl- alpha- phenylcyclopentylglycolate. These compounds are structural isomers and have very similar pharmacological properties. The piperidine compound is the more potent of the two and the reason the mixture was used was because of ease of manufacture, however it is also possible to make the piperidine compound in its pure form, so there were ultimately two forms of Ditran used in research, the original 70/30 mix, and "Ditran-B", the pure piperidine compound. Ditran was developed during chemical weapons research in an attempt to produce non-lethal incapacitating agents, similar to QNB itself. The ditran mixture is more potent as an anticholinergic than the piperidyl benzilate drugs such as N- methyl- 3 -piperidyl benzilate, but is less potent than QNB.
There has been a modest amount of scientific research using this mixture, but most modern research using these kind of anticholinergic drugs uses N- methyl- 3- piperidyl benzilate due to its wider availability.
See also
- N-Methyl-3-piperidyl benzilateN-Methyl-3-piperidyl benzilateN-Methyl-3-piperidyl benzilate is an anticholinergic drug related to the chemical warfare agent 3-Quinuclidinyl benzilate....
- N-Ethyl-3-piperidyl benzilateN-Ethyl-3-piperidyl benzilateN-Ethyl-3-piperidyl benzilate is an anticholinergic drug related to the chemical warfare agent 3-Quinuclidinyl benzilate....
- 3-Quinuclidinyl benzilate3-Quinuclidinyl benzilate3-quinuclidinyl benzilate , IUPAC name 1-azabicyclo[2.2.2]Oct-3-yl α-hydroxy-α-phenylbenzeneacetate, is an odorless military incapacitating agent. Its NATO code is BZ...
- EA-3167EA-3167EA-3167 is a potent and long lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-Quinuclidinyl benzilate . It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, in an attempt to develop non-lethal...