S1PR1 also known as S1P₁ or EDG1 (endothelial differentiation gene 1) is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the S1PR1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

. S1P₁ is a G-protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).

Function

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial

Endothelium

The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. These cells are called endothelial cells. Endothelial cells line the entire circulatory system, from the heart...

 cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell–cell adhesion

Cell adhesion

Cellular adhesion is the binding of a cell to a surface, extracellular matrix or another cell using cell adhesion molecules such as selectins, integrins, and cadherins. Correct cellular adhesion is essential in maintaining multicellular structure...

.

Interactions

S1PR1 has been shown to interact with 5-HT1A receptor

5-HT1A receptor

The 5-HT1A receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin . It is a G protein-coupled receptor that is coupled to Gi/Go and mediates inhibitory neurotransmission...

, GNAI1

GNAI1

Guanine nucleotide-binding protein G, alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.-Interactions:GNAI1 has been shown to interact with GPR143, RGS14, RIC8A, S1PR1, RGS12 and RGS19.-Further reading:...

 and GNAI3

GNAI3

Guanine nucleotide-binding protein G subunit alpha is a protein that in humans is encoded by the GNAI3 gene.-Interactions:GNAI3 has been shown to interact with RGS14, RIC8A, RGS18, S1PR1, RGS12, RGS16, RGS19, RGS10 and RGS5.-Further reading:...

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