EEF1A1
Encyclopedia
Elongation factor 1-alpha 1 is a protein
that in humans is encoded by the EEF1A1 gene
.
In addition to its role in translation, eEF1a has been shown to be play a central role in the nuclear export of proteins. VHL, PABP1
and other proteins containing a TD-NEM (Transcription Dependent Nuclear Export Motif) are exported by eEF1a in a manner that is dependent on ongoing RNA polymerase II
(RNA PolII)-dependent transcription.
with PLCG1
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the EEF1A1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
In addition to its role in translation, eEF1a has been shown to be play a central role in the nuclear export of proteins. VHL, PABP1
PABPC1
Polyadenylate-binding protein 1 is a protein that in humans is encoded by the PABPC1 gene.-Interactions:PABPC1 has been shown to interact with ANAPC5, GSPT2, CNOT7, PAIP1, Eukaryotic translation initiation factor 4 gamma, EIF4G3 and PAIP2....
and other proteins containing a TD-NEM (Transcription Dependent Nuclear Export Motif) are exported by eEF1a in a manner that is dependent on ongoing RNA polymerase II
RNA polymerase II
RNA polymerase II is an enzyme found in eukaryotic cells. It catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA. A 550 kDa complex of 12 subunits, RNAP II is the most studied type of RNA polymerase...
(RNA PolII)-dependent transcription.
Interactions
Eukaryotic translation elongation factor 1 alpha 1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with PLCG1
PLCG1
Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene.-Function:The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate...
.