EH domain-containing protein 1, also known as testilin or PAST homolog 1 (PAST1), is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the EHD1gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

. belonging to the EHD protein family

EHD protein family

The EHD protein family comprises a group of protein that function in intracellular trafficking and that possess a dynamin like structural fold.In humans, four proteins are characterized as belonging to this family:*EHD1*EHD2*EHD3*EHD4...

.

Function

This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15

EPS15

Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.-Interactions:EPS15 has been shown to interact with REPS2, HGS, EPN1, CRK and HRB.-Further reading:...

, a substrate for the epidermal growth factor receptor

Epidermal growth factor receptor

The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family of extracellular protein ligands...

. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors.

Interactions

EHD1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with Insulin-like growth factor 1 receptor and SNAP29

SNAP29

Synaptosomal-associated protein 29 is a protein that in humans is encoded by the SNAP29 gene.-Interactions:SNAP29 has been shown to interact with Syntaxin 3 and EHD1.-Further reading:...

.

Further reading