EIF2AK3
Encyclopedia
Eukaryotic translation initiation factor 2-alpha kinase 3 is an enzyme
that in humans is encoded by the EIF2AK3 gene
. Patients with mutations in this gene develop Wolcott-Rallison syndrome
.
with NFE2L2
and DNAJC3
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the EIF2AK3 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. Patients with mutations in this gene develop Wolcott-Rallison syndrome
Wolcott-Rallison syndrome
Wolcott-Rallison syndrome abbreviated as WRS is a rare, autosomal recessive disorder with infancy-onset diabetes mellitus, multiple epiphyseal dysplasia, osteopenia, mental retardation or developmental delay, and hepatic and renal dysfunction as main clinical findings...
.
Interactions
EIF2AK3 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with NFE2L2
NFE2L2
Nuclear factor -like 2, also known as NFE2L2 or Nrf2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NFE2L2 induces the expression of various genes including those that encode for several antioxidant enzymes, and it may play a physiological role in the regulation of...
and DNAJC3
DNAJC3
DnaJ homolog subfamily C member 3 is a protein that in humans is encoded by the DNAJC3 gene.-Interactions:DNAJC3 has been shown to interact with Protein kinase R, PRKRIR and EIF2AK3.-Further reading:...
.