EPIX Pharmaceuticals Inc
Encyclopedia
EPIX Pharmaceuticals Inc (formerly Predix Pharmaceuticals Inc) was a pharmaceutical company
based in Lexington
, Massachusetts
.
Its products included the following agents:
As of July 2009, the company was in the process of asset liquidation due to insufficient funds to stay afloat.
Pharmaceutical company
The pharmaceutical industry develops, produces, and markets drugs licensed for use as medications. Pharmaceutical companies are allowed to deal in generic and/or brand medications and medical devices...
based in Lexington
Lexington, Massachusetts
Lexington is a town in Middlesex County, Massachusetts, United States. The population was 31,399 at the 2010 census. This town is famous for being the site of the first shot of the American Revolution, in the Battle of Lexington on April 19, 1775.- History :...
, Massachusetts
Massachusetts
The Commonwealth of Massachusetts is a state in the New England region of the northeastern United States of America. It is bordered by Rhode Island and Connecticut to the south, New York to the west, and Vermont and New Hampshire to the north; at its east lies the Atlantic Ocean. As of the 2010...
.
Its products included the following agents:
- PRX-00023PRX-00023PRX-00023 is a drug of the phenylpiperazine class that was being developed by EPIX Pharmaceuticals Inc for the treatment of generalized anxiety disorder and major depressive disorder...
—5-HT1A receptor full agonist (later discovered to actually be an antagonistReceptor antagonistA receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses...
): for major depression and generalized anxiety disorder - PRX-03140—5-HT4 receptor partial agonistPartial agonistPartial agonists bind and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist...
: for Alzheimer's diseaseAlzheimer's diseaseAlzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death... - PRX-07034PRX-07034PRX-07034 is a selective 5-HT6 receptor antagonist. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rodents...
—5-HT6 receptor antagonistReceptor antagonistA receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses...
: for obesityObesityObesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health, leading to reduced life expectancy and/or increased health problems...
and cognitive impairment associated with Alzheimer's diseaseAlzheimer's diseaseAlzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death...
and schizophreniaSchizophreniaSchizophrenia is a mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests itself as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social... - PRX-08066PRX-08066PRX-08066 is a drug developed by EPIX Pharmaceuticals, which acts as a potent and selective antagonist at the serotonin 5-HT2B receptor, with a 5-HT2B binding affinity of 3.4nM, and high selectivity over the closely related 5-HT2A and 5-HT2C receptors and other receptor targets...
—5-HT2B receptor antagonistReceptor antagonistA receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses...
: for pulmonary hypertensionPulmonary hypertensionIn medicine, pulmonary hypertension is an increase in blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, together known as the lung vasculature, leading to shortness of breath, dizziness, fainting, and other symptoms, all of which are exacerbated by exertion...
associated with chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseChronic obstructive pulmonary disease , also known as chronic obstructive lung disease , chronic obstructive airway disease , chronic airflow limitation and chronic obstructive respiratory disease , is the co-occurrence of chronic bronchitis and emphysema, a pair of commonly co-existing diseases...
As of July 2009, the company was in the process of asset liquidation due to insufficient funds to stay afloat.