Edward Tobinick
Encyclopedia
Edward Lewis Tobinick is an American physician
currently in full-time private practice in Los Angeles, California
and he is an Assistant Clinical Professor of Medicine at the David Geffen School of Medicine at UCLA
. Dr. Tobinick is co-author of the recent case report documenting rapid clinical improvement in a patient with Alzheimer's disease following perispinal administration of etanercept which has been received with considerable interest.. Wyeth in collaboration with the University of Southampton has, as of January 2011, begun enrollment into a randomized, placebo-controlled clinical trial of etanercept for patients with Alzheimer's disease. Also being trialed currently, in a multi-center study, is the use of epidural etanercept for sciatica (U.S. patent 6,419,944 issued to Tobinick July 2002), for which favorable randomized, placebo-controlled clinical data from Walter Reed Army Medical Center were published in 2009 (Anesthesiology. 2009 May;110(5):1116-26).
Tobinick has been issued patents for methods of perispinal administration, of certain recombinant DNA-derived (biologic) therapeutics including the TNF
receptor fusion protein etanercept
, for the treatment of certain neurologic disorders with widespread unmet medical need, including Alzheimer's disease; pain due to cancer metastasis to bone; severe, intractable, intervertebral disc-related pain and radiculopathy (including sciatica); and myasthenia gravis. In addition, he originated the concept of the potential utility of etanercept
, alone or in combination with oseltamivir
for treatment of influenza (U.S. patent 6,419,934, filed September 5, 2000 http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=29&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick). For these novel treatment methods he has been issued multiple U.S. patents, including 6,015,557 (Tumor necrosis factor antagonists for the treatment of neurological disorders) http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=41&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick; 6,177,077 http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=35&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick; 6,419,934 http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=29&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick; and 6,982,089 http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=8&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick. In general, his concepts represent emerging therapeutic strategies supported by small pilot studies and expert reviews. (see Publications and References).
Tobinick earned his M.D. from the UC San Diego School of Medicine
in 1977.
Physician
A physician is a health care provider who practices the profession of medicine, which is concerned with promoting, maintaining or restoring human health through the study, diagnosis, and treatment of disease, injury and other physical and mental impairments...
currently in full-time private practice in Los Angeles, California
Los Angeles, California
Los Angeles , with a population at the 2010 United States Census of 3,792,621, is the most populous city in California, USA and the second most populous in the United States, after New York City. It has an area of , and is located in Southern California...
and he is an Assistant Clinical Professor of Medicine at the David Geffen School of Medicine at UCLA
David Geffen School of Medicine at UCLA
UCLA School of Medicine or David Geffen School of Medicine at UCLA is an accredited medical school located in Los Angeles, California, United States...
. Dr. Tobinick is co-author of the recent case report documenting rapid clinical improvement in a patient with Alzheimer's disease following perispinal administration of etanercept which has been received with considerable interest.. Wyeth in collaboration with the University of Southampton has, as of January 2011, begun enrollment into a randomized, placebo-controlled clinical trial of etanercept for patients with Alzheimer's disease. Also being trialed currently, in a multi-center study, is the use of epidural etanercept for sciatica (U.S. patent 6,419,944 issued to Tobinick July 2002), for which favorable randomized, placebo-controlled clinical data from Walter Reed Army Medical Center were published in 2009 (Anesthesiology. 2009 May;110(5):1116-26).
Tobinick has been issued patents for methods of perispinal administration, of certain recombinant DNA-derived (biologic) therapeutics including the TNF
Tumor necrosis factors
Tumor necrosis factors refers to a group of cytokines family that can cause cell death . The first two members of the family to be identified were:...
receptor fusion protein etanercept
Etanercept
Etanercept is a drug that treats autoimmune diseases by interfering with the tumor necrosis factor by acting as a TNF inhibitor. Pfizer describes in a SEC filing that the drug is used to treat rheumatoid, juvenile rheumatoid and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis...
, for the treatment of certain neurologic disorders with widespread unmet medical need, including Alzheimer's disease; pain due to cancer metastasis to bone; severe, intractable, intervertebral disc-related pain and radiculopathy (including sciatica); and myasthenia gravis. In addition, he originated the concept of the potential utility of etanercept
Etanercept
Etanercept is a drug that treats autoimmune diseases by interfering with the tumor necrosis factor by acting as a TNF inhibitor. Pfizer describes in a SEC filing that the drug is used to treat rheumatoid, juvenile rheumatoid and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis...
, alone or in combination with oseltamivir
Oseltamivir
Oseltamivir INN , an antiviral drug, slows the spread of influenza virus between cells in the body by stopping the virus from chemically cutting ties with its host cell; median time to symptom alleviation is reduced by 0.5–1 day. The drug is sold under the trade name Tamiflu, and is taken orally...
for treatment of influenza (U.S. patent 6,419,934, filed September 5, 2000 http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=29&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick). For these novel treatment methods he has been issued multiple U.S. patents, including 6,015,557 (Tumor necrosis factor antagonists for the treatment of neurological disorders) http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=41&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick; 6,177,077 http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=35&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick; 6,419,934 http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=29&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick; and 6,982,089 http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=8&f=G&l=50&co1=AND&d=PTXT&s1=tobinick&OS=tobinick&RS=tobinick. In general, his concepts represent emerging therapeutic strategies supported by small pilot studies and expert reviews. (see Publications and References).
Tobinick earned his M.D. from the UC San Diego School of Medicine
UC San Diego School of Medicine
University of California, San Diego School of Medicine is a medical school located in La Jolla, California, USA.The school held its first class in 1968 and conferred its first degrees in 1972. The school aggressively recruited leading physician scientists of its era and rapidly gained a reputation...
in 1977.