Enoyl-acyl carrier protein reductase (or ENR) , is a key enzyme of the type II fatty acid synthesis (FAS) system. (PMID 15139852) ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes. (PMID 15105103)



At lower concentrations, Triclosan

Triclosan

Triclosan is an antibacterial and antifungal agent. It is a polychloro phenoxy phenol. Despite being used in many consumer products, beyond its use in toothpaste to prevent gingivitis, there is no evidence according to the American Food and Drug Administration that triclosan provides an extra...

 and Triclocarban

Triclocarban

Triclocarban , or 3,4,4'-trichlorocarbanilide, is a substance with anti-bacterial and anti-fungal properties that is used in disinfectants, soaps and other household products....

 provide a bacteriostatic effect by binding to ENR.

See also

• Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific)
  Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific)
  In enzymology, an enoyl-[acyl-carrier-protein] reductase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are acyl-[acyl-carrier-protein] and NADP+, whereas its 3 products are trans-2,3-dehydroacyl-[acyl-carrier-protein], NADPH, and H+.This enzyme belongs...
  
  
• Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific)
  Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific)
  In enzymology, an enoyl-[acyl-carrier-protein] reductase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are acyl-[acyl-carrier-protein] and NADP+, whereas its 3 products are trans-2,3-dehydroacyl-[acyl-carrier-protein], NADPH, and H+.This enzyme belongs...
  
  
• Cis-2-enoyl-CoA reductase (NADPH)
  Cis-2-enoyl-CoA reductase (NADPH)
  In enzymology, a cis-2-enoyl-CoA reductase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are acyl-CoA and NADP+, whereas its 3 products are cis-2,3-dehydroacyl-CoA, NADPH, and H+....