Entner-Doudoroff Pathway
Overview
Glucose
Glucose is a simple sugar and an important carbohydrate in biology. Cells use it as the primary source of energy and a metabolic intermediate...
to pyruvate using a set of enzymes different from those used in either glycolysis
Glycolysis
Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+...
or the pentose phosphate pathway
Pentose phosphate pathway
The pentose phosphate pathway is a process that generates NADPH and pentoses . There are two distinct phases in the pathway. The first is the oxidative phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars...
. Most bacteria use glycolysis and the pentose phosphate pathway. This pathway was first reported in 1952 by Michael Doudoroff
Michael Doudoroff
Michael Doudoroff was an American microbiologist who discovered with Nathan Entner microbial pathway for glucose degradation in some bacteria. Nowadays it is known as Entner–Doudoroff pathway. He was born in St. Petersburg, Russia but moved to San Francisco when he was 12 years old...
(1911–1975) and Nathan Entner.
Distinct features of the Entner–Doudoroff pathway are that it:
- Occurs only in prokaryotes.
- Uses 6-phosphogluconate dehydrase and 2-keto-3-deoxyphosphogluconate aldolase to create pyruvates from glucose.
- Has a net yield of 1 ATP for every glucoseGlucoseGlucose is a simple sugar and an important carbohydrate in biology. Cells use it as the primary source of energy and a metabolic intermediate...
molecule processed, as well as 1 NADH and 1 NADPH.