Epalrestat
Encyclopedia
Epalrestat is an aldose reductase inhibitor
.
"Long-term treatment with epalrestat is well tolerated and can effectively delay the progression of diabetic neuropathy
and ameliorate the associated symptoms of the disease, particularly in subjects with good glycemic control and limited microangiopathy."
Aldose reductase inhibitor
Aldose reductase inhibitors are a class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes.-Mechanism:Their target, aldose reductase, is an enzyme that is normally present in many other parts of the body, and catalyzes one of the steps in the sorbitol pathway...
.
"Long-term treatment with epalrestat is well tolerated and can effectively delay the progression of diabetic neuropathy
Diabetic neuropathy
Diabetic neuropathies are neuropathic disorders that are associated with diabetes mellitus. These conditions are thought to result from diabetic microvascular injury involving small blood vessels that supply nerves in addition to macrovascular conditions that can culminate in diabetic neuropathy...
and ameliorate the associated symptoms of the disease, particularly in subjects with good glycemic control and limited microangiopathy."
External links
- Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy. (2008 review of 6 clinical trials)
- Epalrestat at chemblink.com