The epitympanic recess is a hollow located on the superior/roof aspect of the middle ear

Middle ear

The middle ear is the portion of the ear internal to the eardrum, and external to the oval window of the cochlea. The mammalian middle ear contains three ossicles, which couple vibration of the eardrum into waves in the fluid and membranes of the inner ear. The hollow space of the middle ear has...

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Clinical significance

This recess is a possible route of spread of infection to the mastoid air cells located in the mastoid process

Mastoid process

The mastoid process is a conical prominence projecting from the undersurface of the mastoid portion of the temporal bone. It is located just behind the external acoustic meatus, and lateral to the styloid process...

 of the temporal bone of the skull. Inflammation

Inflammation

Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli and to initiate the healing process...

 which has spread to the mastoid air cells is very difficult to drain and causes considerable pain. Before the advent of antibiotic

Antibiotic

An antibacterial is a compound or substance that kills or slows down the growth of bacteria.The term is often used synonymously with the term antibiotic; today, however, with increased knowledge of the causative agents of various infectious diseases, antibiotic has come to denote a broader range of...

s it could only be drained by drilling a hole in the mastoid bone, a process known as mastoidectomy.