Equagesic is a combination drug indicated for short-term pain treatment accompanied by tension

Stress (biology)

Stress is a term in psychology and biology, borrowed from physics and engineering and first used in the biological context in the 1930s, which has in more recent decades become commonly used in popular parlance...

 or anxiety

Anxiety

Anxiety is a psychological and physiological state characterized by somatic, emotional, cognitive, and behavioral components. The root meaning of the word anxiety is 'to vex or trouble'; in either presence or absence of psychological stress, anxiety can create feelings of fear, worry, uneasiness,...

 in patients with musculoskeletal disorders

Musculoskeletal disorders

Musculoskeletal disorders can affect the body's muscles, joints, tendons, ligaments and nerves. Most work-related MSDs develop over time and are caused either by the work itself or by the employees' working environment...

 or tension headache

Tension headache

A tension headache is the most common type of primary headache. The pain can radiate from the neck, back, eyes, or other muscle groups in the body. Tension-type headaches account for nearly 90% of all headaches...

.

Composition

It combines

• aspirin
  Aspirin
  Aspirin , also known as acetylsalicylic acid , is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. It was discovered by Arthur Eichengrun, a chemist with the German company Bayer...
  
   325mg (for pain relief) and
• meprobamate
  Meprobamate
  Meprobamate is a carbamate derivative which is used as an anxiolytic drug...
  
   200mg (used here as a muscle relaxant
  Muscle relaxant
  A muscle relaxant is a drug which affects skeletal muscle function and decreases the muscle tone. It may be used to alleviate symptoms such as muscle spasms, pain, and hyperreflexia. The term "muscle relaxant" is used to refer to two major therapeutic groups: neuromuscular blockers and spasmolytics...
  
  ).
• In some formulations it is also quoted to contain ethoheptazine
  Ethoheptazine
  Ethoheptazine is an opioid analgesic from the phenazepine family. It was invented in the 1950s and is related to other drugs such as proheptazine....
  
  , an opioid
  Opioid
  An opioid is a psychoactive chemical that works by binding to opioid receptors, which are found principally in the central and peripheral nervous system and the gastrointestinal tract...
  
   analgesic.

Problems

Equagesic was discontinued in the United States

United States

The United States of America is a federal constitutional republic comprising fifty states and a federal district...

, possibly because of its toxic profile and more adequate drugs available. Specifically, meprobamate is more toxic than benzodiazepine

Benzodiazepine

A benzodiazepine is a psychoactive drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring...

s, which are also useful as a muscle relaxant.

Martial artist Bruce Lee

Bruce Lee

Bruce Lee was a Chinese American, Hong Kong actor, martial arts instructor, philosopher, film director, film producer, screenwriter, and founder of the Jeet Kune Do martial arts movement...

 died of cerebral edema

Cerebral edema

Cerebral edema or cerebral œdema is an excess accumulation of water in the intracellular or extracellular spaces of the brain.-Vasogenic:Due to a breakdown of tight endothelial junctions which make up the blood-brain barrier...

 caused by allergic reaction

Allergy

An Allergy is a hypersensitivity disorder of the immune system. Allergic reactions occur when a person's immune system reacts to normally harmless substances in the environment. A substance that causes a reaction is called an allergen. These reactions are acquired, predictable, and rapid...

 to Equagesic, according to coroner

Coroner

A coroner is a government official who* Investigates human deaths* Determines cause of death* Issues death certificates* Maintains death records* Responds to deaths in mass disasters* Identifies unknown dead* Other functions depending on local laws...

examination.