Femarelle is as a selective estrogen receptor modulator

Selective estrogen receptor modulator

Selective Estrogen Receptor Modulators are a class of compounds that act on the estrogen receptor. A characteristic that distinguishes these substances from pure receptor agonists and antagonists is that their action is different in various tissues, thereby granting the possibility to selectively...

 (SERM) for the treatment of menopause

Menopause

Menopause is a term used to describe the permanent cessation of the primary functions of the human ovaries: the ripening and release of ova and the release of hormones that cause both the creation of the uterine lining and the subsequent shedding of the uterine lining...

 and bone health. DT56a is a standardized compound derived from soybean

Soybean

The soybean or soya bean is a species of legume native to East Asia, widely grown for its edible bean which has numerous uses...

.

Mode of Action

In animal models, Femarelle exerts agonistic (stimulatory) activity on estrogen receptor

Estrogen receptor

Estrogen receptor refers to a group of receptors that are activated by the hormone 17β-estradiol . Two types of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and the estrogen G protein-coupled receptor GPR30 , which is a G protein-coupled...

s in the brain and bone. The compound has been reported to alleviate menopausal symptoms such as hot flushes and elevate bone mineral density (BMD), while having no proliferative effects on isolated breast cancer cell lines and uterine tissues of rats.
Femarelle was found to regenerate the bone through increased osteoblast

Osteoblast

Osteoblasts are mononucleate cells that are responsible for bone formation; in essence, osteoblasts are specialized fibroblasts that in addition to fibroblastic products, express bone sialoprotein and osteocalcin.Osteoblasts produce a matrix of osteoid, which is composed mainly of Type I collagen...

activity, which makes it a possible agent for postmenopausal bone loss.
Although stimulating estrogen receptors, Femarelle does not appear to change the hormonal blood profile. A recent study found that Femarelle has no effect on clotting in both healthy and thrombophilic women.

Trade Names

Femarelle (Finland, Greece, Italy, Spain, Israel, USA, India, Latvia, Lithuania, Estonia, Norway, Sweden)

Tofupill (Cyprus, Mexico)